Division of Oral Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Int J Oral Maxillofac Surg. 2010 Feb;39(2):161-8. doi: 10.1016/j.ijom.2009.12.006. Epub 2010 Jan 8.
The authors have reported that a scaffold constructed of synthetic octacalcium phosphate (OCP) and porcine atelocollagen sponge (OCP/Col) enhanced bone regeneration more than sintered beta-tricalcium phosphate collagen composite or sintered hydroxyapatite collagen composite with a rat calvarial defect model. To aim for clinical application, the present study investigated whether OCP/Col would enhance bone healing in a dog tooth extraction socket model. Six adult, male, beagle dogs were used. The tooth extraction socket model was made by extracting bilateral third maxillary incisors and the subsequent removal of buccal bone. Disks of OCP/Col were implanted into one side of the model and the other side was untreated. The specimens were fixed 1 or 3 months after implantation. In radiographic analysis, the OCP/Col-treated group showed a wider range of radiopacity than the untreated control. Histologically, the OCP/Col-treated group showed more abundant newly formed bone than untreated control, and the implanted OCP was gradually resorbed. In morphometrical analysis, enlargement of the buccal alveolus in the OCP/Col group was significantly greater than in the untreated control. This study showed that implanted OCP/Col would be replaced by newly formed bone and OCP/Col implantation would enhance bone healing in a tooth socket model.
作者曾报道，一种由合成的八钙磷酸盐（OCP）和猪去端肽胶原海绵（OCP/Col）构建的支架在大鼠颅顶骨缺损模型中比烧结β-磷酸三钙胶原复合材料或烧结羟磷灰石胶原复合材料更能促进骨再生。为了实现临床应用，本研究探讨了 OCP/Col 是否会增强犬拔牙窝模型中的骨愈合。使用 6 只成年雄性比格犬。通过拔除双侧第三上颌切牙和随后去除颊骨来制作拔牙窝模型。将 OCP/Col 圆盘植入模型的一侧，另一侧不处理。植入后 1 或 3 个月固定标本。在放射学分析中，OCP/Col 治疗组的射线不透明度范围比未处理的对照组更广。组织学上，OCP/Col 治疗组显示出比未处理对照组更丰富的新骨形成，并且植入的 OCP 逐渐被吸收。在形态计量学分析中，OCP/Col 组颊牙槽的扩大明显大于未处理对照组。本研究表明，植入的 OCP/Col 将被新形成的骨取代，OCP/Col 植入可增强拔牙窝模型中的骨愈合。
