Leuven Centre of Cancer Prevention, University Hospitals-Leuven, Belgium.
Crit Rev Oncol Hematol. 2010 Sep;75(3):243-8. doi: 10.1016/j.critrevonc.2009.12.002. Epub 2010 Jan 13.
The use of comprehensive geriatric assessment (CGA) in cancer patients older than 70 is recommended. Three pre-screening instruments have been proposed: the abbreviated comprehensive geriatric assessment (aCGA), the Vulnerable Elders Survey (VES-13), and the Groningen frailty index (GFI). The objective of the study was to identify the most efficient pre-screening tool that accurately determines individuals who may benefit from the entire CGA. A total of 113 elderly cancer patients were assessed by means of the aCGA, VES-13, GFI and the full CGA. The sensitivity, specificity of the three instruments was calculated, using the results from the entire CGA as the gold standard for the GFI and the VES-13. The aCGA was assessed whether each sub-component reliably predicts impairment on each sub-component of the full CGA. The majority of the participants were defined as being at risk of vulnerability: 68.14% had two or more impairments of the CGA or were cognitively impaired. The physical and disability questions are useful, but all other screening instruments miss too many cases.
推荐对 70 岁以上的癌症患者使用全面老年评估（CGA）。已经提出了三种预筛选工具：简化全面老年评估（aCGA）、脆弱老年人调查（VES-13）和格罗宁根虚弱指数（GFI）。本研究的目的是确定最有效的预筛选工具，该工具可以准确确定可能受益于整个 CGA 的个体。共对 113 名老年癌症患者进行了 aCGA、VES-13、GFI 和完整 CGA 的评估。使用整个 CGA 的结果作为 GFI 和 VES-13 的金标准，计算了这三种仪器的灵敏度和特异性。评估了 aCGA 的每个亚成分是否可靠地预测了完整 CGA 的每个亚成分的损伤。大多数参与者被定义为处于脆弱风险中：68.14%的人有两个或更多的 CGA 损伤或认知障碍。身体和残疾问题是有用的，但所有其他筛选工具都错过了太多病例。
