Department of Pharmacology, College of Medicine, University of Illinois, Chicago, IL 60612, USA.
Curr Opin Pharmacol. 2010 Apr;10(2):127-32. doi: 10.1016/j.coph.2009.11.010. Epub 2010 Jan 7.
Mammalian TRP channels are grouped into six subfamilies (TRPC, TRPM, TRPV, TRPA, TRPP, and TRPML) based on the homology of the amino acid sequence. They are nonselective cation-permeable channels, most of which are permeable for Ca(2+). Growing evidence demonstrates important roles of TRP channel in controlling vascular function including endothelial permeability, responses to oxidative stress, myogenic tone, cellular proliferative activity, and thermoregulation. TRP channels are activated by a variety of stimuli, including calcium store depletion, mechanical perturbations, receptor activation, and changes in temperature and osmolarity. This diversity of activating mechanisms could be consistent with the potential multiple functions of the TRP superfamily. This review summarizes the burgeoning understanding of these cation channels in the control of vascular function.
哺乳动物 TRP 通道根据氨基酸序列的同源性分为六个亚家族（TRPC、TRPM、TRPV、TRPA、TRPP 和 TRPML）。它们是非选择性阳离子通透通道，大多数通道对 Ca(2+)是通透的。越来越多的证据表明，TRP 通道在控制血管功能方面起着重要作用，包括内皮通透性、对氧化应激的反应、肌原性张力、细胞增殖活性和体温调节。TRP 通道可被多种刺激激活，包括钙库耗竭、机械扰动、受体激活以及温度和渗透压的变化。这种激活机制的多样性可能与 TRP 超家族的多种潜在功能相一致。本文综述了这些阳离子通道在血管功能调控中的研究进展。
