Department of Physiology, Cell Physiology Research Group, University of Extremadura, 10003, Cáceres, Spain.
Curr Vasc Pharmacol. 2013 Jul;11(4):480-9. doi: 10.2174/1570161111311040011.
The TRP family of cation-permeable channels owes its name to a Drosophila TRP mutant with impaired vision due to transient rather than sustained receptor potential. Mammalian TRP channels can be grouped into 6 subfamilies, including TRPC, TRPM, TRPV, TRPA, TRPP and TRPML and a number of TRP family members have been identified in the vasculature. TRP channels play an important functional role in the vasculature as mediators of cation influx across the plasma membrane, thus contributing to a large number of processes such as vascular smooth muscle contraction and vascular pressure or the responses to oxidative stress, mechanical stimuli, heat and hypoxia-induced vascular remodelling. TRP channelopaties are involved in the pathogenesis of different disorders including hypertension and cardiomyopathy. A number of identified natural compounds and synthetic agents have been reported to modulate TRP function, and are the base for therapeutical strategies.
瞬时而非持续受体电位导致果蝇 TRP 突变体视力受损，TRP 家族阳离子渗透性通道因此得名。哺乳动物 TRP 通道可分为 6 个亚家族，包括 TRPC、TRPM、TRPV、TRPA、TRPP 和 TRPML，在血管系统中已经鉴定出许多 TRP 家族成员。TRP 通道在血管系统中作为阳离子跨质膜内流的介体发挥重要的功能作用，从而参与许多过程，如血管平滑肌收缩和血管压力或对氧化应激、机械刺激、热和低氧诱导的血管重塑的反应。TRP 通道病参与包括高血压和心肌病在内的不同疾病的发病机制。已经报道了许多已鉴定的天然化合物和合成剂可调节 TRP 功能，并作为治疗策略的基础。
