Sarcoma Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
Eur J Surg Oncol. 2010 May;36(5):477-82. doi: 10.1016/j.ejso.2009.12.005. Epub 2010 Jan 8.
The role of radiofrequency ablation (RFA) in metastatic sarcoma is not well defined. The aim of this study was to evaluate the efficacy and safety of RFA in a series of sarcoma patients. A retrospective search of a prospectively maintained database identified 13 gastrointestinal stromal tumour (GIST) patients and 12 with other histological subtypes treated with RFA. All the GIST patients received RFA for metastatic disease in the liver: 12 of these responded to the first RFA procedure and one achieved stable disease. Two GIST patients received RFA on two occasions to separate lesions within the liver and both responded to the second RFA procedure. Of the other subtypes: 7 underwent RFA to liver lesions, 5 of these responded to RFA, one progressed and 1 was not assessable for response at the time of analysis. All 5 patients with lung metastases achieved a response following their first RFA procedure. RFA was effective and well tolerated in this series of sarcoma patients. RFA may have a role in patients with GIST who have progression in a single metastasis but stable disease elsewhere. Further larger studies are required to better define the role of this technique in this patient population.
射频消融 (RFA) 在转移性肉瘤中的作用尚未明确。本研究旨在评估 RFA 在一系列肉瘤患者中的疗效和安全性。通过对前瞻性维护的数据库进行回顾性检索，确定了 13 例胃肠道间质瘤 (GIST) 患者和 12 例其他组织学亚型患者接受 RFA 治疗。所有 GIST 患者均因肝转移接受了 RFA 治疗：其中 12 例对首次 RFA 治疗有反应，1 例达到疾病稳定。2 例 GIST 患者在肝脏的不同部位接受了 2 次 RFA 治疗，均对第二次 RFA 治疗有反应。其他亚型患者中：7 例接受了肝转移灶的 RFA，其中 5 例对 RFA 有反应，1 例进展，1 例在分析时无法评估反应。所有 5 例肺转移患者在首次 RFA 后均有反应。在本系列肉瘤患者中，RFA 是有效且耐受良好的。对于在单个转移灶中进展但其他部位稳定的 GIST 患者，RFA 可能具有一定作用。需要进一步的大型研究来更好地确定该技术在这一患者群体中的作用。
