病毒基因组包装。
Genome packaging in viruses.
机构信息
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-2054, USA.
出版信息
Curr Opin Struct Biol. 2010 Feb;20(1):114-20. doi: 10.1016/j.sbi.2009.12.006. Epub 2010 Jan 8.
Abstract
Genome packaging is a fundamental process in a viral life cycle. Many viruses assemble preformed capsids into which the genomic material is subsequently packaged. These viruses use a packaging motor protein that is driven by the hydrolysis of ATP to condense the nucleic acids into a confined space. How these motor proteins package viral genomes had been poorly understood until recently, when a few X-ray crystal structures and cryo-electron microscopy (cryo-EM) structures became available. Here we discuss various aspects of genome packaging and compare the mechanisms proposed for packaging motors on the basis of structural information.
摘要
基因组包装是病毒生命周期中的一个基本过程。许多病毒将预先形成的衣壳组装在一起，随后将基因组物质包装进去。这些病毒使用一种包装马达蛋白，该蛋白通过 ATP 的水解来驱动，将核酸浓缩到一个受限的空间中。直到最近，当一些 X 射线晶体结构和低温电子显微镜（cryo-EM）结构可用时，这些马达蛋白如何包装病毒基因组才得到了很好的理解。在这里，我们讨论基因组包装的各个方面，并根据结构信息比较包装马达提出的机制。
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