Erasmus MC Sophia, Room SB-2603, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands.
J Clin Endocrinol Metab. 2010 Feb;95(2):864-71. doi: 10.1210/jc.2009-1508. Epub 2010 Jan 8.
IGF binding protein (IGFBP)-2 might protect against cardiovascular disease. Small for gestational age (SGA) birth could be associated with a higher risk for type 2 diabetes mellitus and cardiovascular disease in later life. No data are available on the relationship between serum IGFBP-2 levels and cardiovascular risk factors in young adults and children born SGA.
The aim of the study was to determine circulating IGFBP-2 levels in subjects born SGA and to investigate the association with cardiovascular risk factors.
IGFBP-2 levels were measured in sera from 151 young adults born SGA and 147 short SGA children. Age- and gender-adjusted sd scores (SDS) were calculated. We determined blood pressure, serum lipids, body composition by dual-energy x-ray absorptiometry, and glucose homeostasis by homeostasis model of assessment for insulin resistance or frequently sampled iv glucose tolerance test.
Serum IGFBP-2 SDS was significantly reduced in SGA young adults (with normal or short stature). Fat mass SDS was relatively high in SGA young adults and was reduced in short SGA children. Serum IGFBP-2 SDS in SGA young adults correlated positively with insulin sensitivity and negatively with fat mass SDS, insulin secretion (acute insulin response), fasting insulin, homeostasis model of assessment for insulin resistance, total cholesterol, triglycerides, and blood pressure SDS. The association between serum IGFBP-2 SDS and insulin sensitivity, blood pressure, total cholesterol, and triglyceride levels persisted after adjustment for known covariates including fat mass SDS. In short SGA children, IGFBP-2 SDS did not correlate with any of the cardiovascular risk factors.
In young adults who were born SGA, serum IGFBP-2 levels associate with cardiovascular risk markers.
胰岛素样生长因子结合蛋白-2（IGFBP-2）可能对心血管疾病有保护作用。小于胎龄儿（SGA）出生可能与成年后患 2 型糖尿病和心血管疾病的风险增加有关。目前尚无关于 SGA 出生的年轻成年人和儿童血清 IGFBP-2 水平与心血管危险因素之间关系的数据。
本研究旨在确定 SGA 出生的受试者中循环 IGFBP-2 水平，并探讨其与心血管危险因素的关系。
测量了 151 名 SGA 出生的年轻成年人和 147 名 SGA 矮小儿童的血清 IGFBP-2 水平。计算了年龄和性别调整后的标准差（SDS）。我们测定了血压、血清脂质、双能 X 线吸收法测定的身体成分以及稳态模型评估的胰岛素抵抗或频繁采样静脉葡萄糖耐量试验评估的葡萄糖稳态。
SGA 年轻成年人（身高正常或矮小）的血清 IGFBP-2 SDS 显著降低。SGA 年轻成年人的脂肪量 SDS 相对较高，而 SGA 矮小儿童的脂肪量 SDS 降低。SGA 年轻成年人的血清 IGFBP-2 SDS 与胰岛素敏感性呈正相关，与脂肪量 SDS、胰岛素分泌（急性胰岛素反应）、空腹胰岛素、胰岛素抵抗评估的稳态模型、总胆固醇、甘油三酯和血压 SDS 呈负相关。在调整了已知协变量（包括脂肪量 SDS）后，血清 IGFBP-2 SDS 与胰岛素敏感性、血压、总胆固醇和甘油三酯水平之间的相关性仍然存在。在 SGA 矮小儿童中，IGFBP-2 SDS 与任何心血管危险因素均无相关性。
在 SGA 出生的年轻成年人中，血清 IGFBP-2 水平与心血管风险标志物相关。
