Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA.
MAbs. 2009 Mar-Apr;1(2):112-4. doi: 10.4161/mabs.1.2.7829. Epub 2009 Mar 11.
Immunotherapy approaches for Alzheimer disease currently are among the leading therapeutic directions for the disease. Active and passive immunotherapy against the beta-amyloid peptides that aggregate and accumulate in the brain of those afflicted by the disease have been shown by numerous groups to reduce plaque pathology and improve behavior in transgenic mouse models of the disease. Several ongoing immunotherapy clinical trials for Alzheimer disease are in progress. The background and ongoing challenges for these immunological approaches for the treatment of Alzheimer disease are discussed.
阿尔茨海默病的免疫疗法目前是该病的主要治疗方向之一。许多研究小组已经证明，针对在疾病患者大脑中聚集和积累的β-淀粉样肽的主动和被动免疫疗法可以减少斑块病理，并改善疾病转基因小鼠模型的行为。目前正在进行几项针对阿尔茨海默病的免疫疗法临床试验。本文讨论了这些用于治疗阿尔茨海默病的免疫方法的背景和当前挑战。
