BIOAIR (Laboratory of Biomolecular and Bioengineering Airways), University of Florence, Florenz, Italy.
Transplantation. 2010 Mar 15;89(5):485-91. doi: 10.1097/TP.0b013e3181cd4ad3.
Regenerative medicine offers new tools with which to tackle disorders for which there is currently no good therapeutic option. The trachea is an ideal organ in which to explore the clinical potential of tissue engineering because severe large airway disease is poorly managed by conventional treatments, and the success of a graft is determined only by its ability to conduct air lifelong: that is, whether it can become a sustainable biological conduit. We define the component parts of tissue engineering and review the experimental methods used to produce airway implants to date, including a recent successful, first-in-man experience.
再生医学提供了新的工具，可以用于治疗目前尚无良好治疗选择的疾病。气管是探索组织工程临床潜力的理想器官，因为严重的大气道疾病用传统治疗方法难以控制，移植物的成功仅取决于其终生通气的能力，也就是说，它是否能成为一种可持续的生物导管。我们定义了组织工程的组成部分，并回顾了迄今为止用于生产气道植入物的实验方法，包括最近的首例人体成功经验。
