Curran H V, Schifano F, Lader M
Department of Psychiatry, Institute of Psychiatry, London, UK.
Psychopharmacology (Berl). 1991;103(1):83-90. doi: 10.1007/BF02244079.
The effects on memory, psychomotor functions and mood of intramuscular scopolamine (0.3 mg, 0.6 mg) were compared with those of oral lorazepam (2 mg) and placebo. Thirty-six volunteers took part in a double-blind, independent groups design. Subjects completed a battery of tests 1 and 3 h after drug administration. Both doses of scopolamine produced levels of sedation comparable to that produced by lorazepam. The time course of effects of scopolamine and lorazepam differed but the pattern of psychomotor impairments and amnestic effects produced was very similar. In terms of mood, lorazepam had an anxiolytic effect whereas scopolamine increased ratings of anxiety. Levels of sedation, indexed by either subjective ratings or motor retardation (tapping speed), were related more to psychomotor performance than to performance on memory tasks. The results suggest that benzodiazepines and scopolamine have similar amnestic and sedative effects and as such may not offer distinct models of memory dysfunction.
将肌肉注射东莨菪碱（0.3毫克、0.6毫克）与口服劳拉西泮（2毫克）及安慰剂对记忆、精神运动功能和情绪的影响进行了比较。36名志愿者参与了一项双盲、独立组设计的研究。受试者在给药后1小时和3小时完成了一系列测试。两种剂量的东莨菪碱产生的镇静水平与劳拉西泮产生的相当。东莨菪碱和劳拉西泮的作用时间进程不同，但产生的精神运动障碍和遗忘效应模式非常相似。在情绪方面，劳拉西泮有抗焦虑作用，而东莨菪碱则增加了焦虑评分。由主观评分或运动迟缓（敲击速度）所指示的镇静水平，与精神运动表现的相关性比与记忆任务表现的相关性更大。结果表明，苯二氮䓬类药物和东莨菪碱具有相似的遗忘和镇静作用，因此可能无法提供不同的记忆功能障碍模型。
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