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曲妥珠单抗(赫赛汀)在孕期的安全性:两例病例报告。

Safety of trastuzumab (Herceptin) during pregnancy: two case reports.

作者信息

Goodyer Matthew J, Ismail Jeffri Rm, O'Reilly Seamus P, Moylan Eugene J, Ryan C Anthony M, Hughes Paul Af, O'Connor Alan

机构信息

Department of Medical Oncology, Cork University Hospital, Cork, Ireland.

出版信息

Cases J. 2009 Dec 16;2:9329. doi: 10.1186/1757-1626-2-9329.

Abstract

We report on two cases of women on trastuzumab therapy for breast cancer who became pregnant and delivered healthy live infants. At the time of reporting the children are growing and developing normally (ages 3 and 2).

摘要

我们报告了两例接受曲妥珠单抗治疗乳腺癌的女性怀孕并生下健康活产婴儿的病例。在报告时,这些孩子生长发育正常(年龄分别为3岁和2岁)。

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Trastuzumab in pregnancy associated with poor fetal outcome.
Ann Oncol. 2008 Jan;19(1):191-2. doi: 10.1093/annonc/mdm542. Epub 2007 Dec 15.
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Trastuzumab use for metastatic breast cancer in pregnancy.曲妥珠单抗在妊娠期转移性乳腺癌中的应用。
Obstet Gynecol. 2007 Aug;110(2 Pt 2):507-10. doi: 10.1097/01.AOG.0000267133.65430.44.
4
Favorable pregnancy outcome following Trastuzumab (Herceptin) use during pregnancy--Case report and updated literature review.
Reprod Toxicol. 2007 Jun;23(4):611-3. doi: 10.1016/j.reprotox.2007.02.003. Epub 2007 Feb 25.
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Effect of adjuvant trastuzumab on pregnancy.
J Clin Oncol. 2006 Jan 10;24(2):321-2. doi: 10.1200/JCO.2005.04.6607.

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