Batra Ramesh, Davies Jonathan N, Wheatley Duncan
Surgical Directorate, Royal Cornwall Hospitals NHS Trust, Truro, UK.
Cases J. 2009 Nov 24;2:9082. doi: 10.1186/1757-1626-2-9082.
Germ cell tumours tend to affect young adults and with advanced treatments achieve more than 90% cure rates. Over the years cisplatin has significantly improved the relapse free survival in these patients, hence forming an essential component of chemotherapy regimes. But, the thrombo-embolic complications suffered with cisplatin significantly affect the quality of life in these young patients.We describe a young adult who suffered a potentially fatal cerebral and pulmonary vascular insult on completing first cycle of cisplatin-based chemotherapy for a non-seminomatous germ cell tumour. Venous and arterial thrombo-embolism was the mechanism of injury and was promptly managed surgically and medically including neuro-rehabilitation.
生殖细胞肿瘤往往影响年轻成年人,先进的治疗方法可使治愈率超过90%。多年来,顺铂显著提高了这些患者的无复发生存率,因此成为化疗方案的重要组成部分。但是,顺铂引发的血栓栓塞并发症严重影响了这些年轻患者的生活质量。我们描述了一名年轻成年人,他在完成基于顺铂的非精原性生殖细胞肿瘤化疗第一周期后,遭受了可能致命的脑和肺血管损伤。静脉和动脉血栓栓塞是损伤机制,通过手术和药物进行了及时治疗,包括神经康复治疗。