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一名低分化神经内分泌肿瘤患者出现双循环致命性副肿瘤性栓塞。

Fatal paraneoplastic embolisms in both circulations in a patient with poorly differentiated neuroendocrine tumour.

作者信息

Busch A, Tschernitz S, Thurner A, Kellersmann R, Lorenz U

机构信息

Department of General, Visceral, Vascular and Paediatric Surgery, Julius Maximilians University of Wuerzburg, Oberduerrbacher Street 6, 97080 Wuerzburg, Germany.

Institute of Pathology, Julius Maximilians University of Wuerzburg, Oberduerrbacher Street 6, 97080 Wuerzburg, Germany.

出版信息

Case Rep Vasc Med. 2013;2013:739427. doi: 10.1155/2013/739427. Epub 2013 Dec 30.

DOI:10.1155/2013/739427
PMID:24490097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3893835/
Abstract

Arterial embolism with lower limb ischemia is a rare manifestation of paraneoplastic hypercoagulability in cancer patients. We report a unique case of fatal thromboembolism involving both circulations associated with a poorly differentiated neuroendocrine tumor of the lung with rapid progress despite high doses of unfractioned heparin and review the current literature on anticoagulative regimen in tumour patients.

摘要

动脉栓塞伴下肢缺血是癌症患者副肿瘤性高凝状态的一种罕见表现。我们报告了一例独特的致命性血栓栓塞病例，累及双循环，与低分化肺神经内分泌肿瘤相关，尽管使用了大剂量普通肝素仍进展迅速，并回顾了目前关于肿瘤患者抗凝方案的文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c748/3893835/924147c3dbac/CRIM.VASMED2013-739427.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c748/3893835/6d1b8b51c34d/CRIM.VASMED2013-739427.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c748/3893835/924147c3dbac/CRIM.VASMED2013-739427.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c748/3893835/6d1b8b51c34d/CRIM.VASMED2013-739427.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c748/3893835/924147c3dbac/CRIM.VASMED2013-739427.002.jpg

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本文引用的文献

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Anticoagulation for prevention and treatment of cancer-related venous thromboembolism.癌症相关静脉血栓栓塞症的预防和治疗中的抗凝治疗。
Br J Haematol. 2013 Jun;161(6):764-77. doi: 10.1111/bjh.12314. Epub 2013 Apr 5.
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Clinical use of the low-molecular-weight heparins in cancer patients: focus on the improved patient outcomes.低分子量肝素在癌症患者中的临床应用：聚焦于改善患者预后。
Thrombosis. 2011;2011:530183. doi: 10.1155/2011/530183. Epub 2011 Apr 12.
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Low molecular weight heparin versus unfractionated heparin for perioperative thromboprophylaxis in patients with cancer.
以孤立性肺结节形式出现的弥漫性特发性肺神经内分泌细胞增生：一种罕见的组织病理学诊断。
Oxf Med Case Reports. 2022 Sep 26;2022(9):omac069. doi: 10.1093/omcr/omac069. eCollection 2022 Sep.
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BMC Cancer. 2016 Mar 10;16:203. doi: 10.1186/s12885-016-2233-1.
低分子量肝素与普通肝素用于癌症患者围手术期血栓预防的比较
Cochrane Database Syst Rev. 2011 Nov 9(11):CD009447. doi: 10.1002/14651858.CD009447.
4
Severe systemic vasoconstriction starting with acute limb ischemia leading to death in a patient with well-differentiated pulmonary neuroendocrine carcinoma: a new paraneoplastic syndrome?一名高分化肺神经内分泌癌患者出现以急性肢体缺血为起始的严重全身性血管收缩并导致死亡：一种新的副肿瘤综合征？
Acta Oncol. 2012 Jan;51(1):124-7. doi: 10.3109/0284186X.2011.602115. Epub 2011 Aug 22.
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Anticoagulation in the management of venous thromboembolism in the cancer patient.癌症患者静脉血栓栓塞症的抗凝治疗。
J Thromb Thrombolysis. 2011 Apr;31(3):282-94. doi: 10.1007/s11239-011-0562-0.
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Phaeochromocytoma-associated critical peripheral ischaemia.嗜铬细胞瘤相关危重心外周缺血。
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