在实验室模型生态系统中评估三种致癌物——苯并（α）芘、联苯胺和氯乙烯的环境归宿。
The Environmental fate of three carcinogens: benzo-(alpha)-pyrene, benzidine, and vinyl chloride evaluated in laboratory model ecosystems.
作者信息
Lu P Y, Metcalf R L, Plummer N, Mandel D
出版信息
Arch Environ Contam Toxicol. 1977;6(2-3):129-42. doi: 10.1007/BF02097756.
Radiolabeled benzo-((alpha)-pyrene, benzidine, and vinyl chloride were evaluated in laboratory model ecosystems for environmental fate, degradation pathways, bioconcentration, and food chain accumulation. The comparative effects of microsomal detoxications were evaluated using the inhibitor piperonyl butoxide. The accumulation and bioconcentration of benzo-(alpha)-pyrene and benzidine were closely correlated with their octanol/water partition coefficients and water solubility. Benzo-(alpha)-pyrene as predicted by these parameters was bioaccumulated to substantial levels in several organisms. Vinyl chloride was not accumulated because of its high volatility.
在实验室模型生态系统中评估了放射性标记的苯并（α）芘、联苯胺和氯乙烯的环境归宿、降解途径、生物富集以及食物链积累情况。使用抑制剂胡椒基丁醚评估了微粒体解毒的比较效果。苯并（α）芘和联苯胺的积累和生物富集与它们的正辛醇/水分配系数和水溶性密切相关。根据这些参数预测，苯并（α）芘在几种生物体中生物累积到了相当高的水平。氯乙烯由于其高挥发性而未被积累。
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