Institute of Physiology, Medical Faculty, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia.
Clin Auton Res. 2010 Jun;20(3):183-90. doi: 10.1007/s10286-009-0050-1. Epub 2010 Jan 9.
The pathophysiology of the pregnancy-induced hypertension is still poorly understood, especially with regard to the central autonomic nervous system control and peripheral vascular factors.
Our study therefore aimed to investigate simultaneously the responses of blood pressure, heart rate, heart rate variability (HRV), and laser-Doppler (LD) flux to local cooling in healthy non-pregnant women (N = 12), in pregnant women with normal pregnancy (N = 16) and in women with gestational hypertension (N = 10).
The direct and indirect LD flux responses to local cold exposure were diminished in normotensive pregnant females (Dunnett's test, p < 0.05) when compared to non-pregnant females with normal menstrual cycle, but not in females with pregnancy-induced hypertension. In addition, blood pressure increased and heart rate decreased during cold exposure only in normotensive pregnant females, but not in pregnant hypertensive females (paired t test, p < 0.05). Simultaneously calculated heart rate variability total power of HRV and LF power values typically increased during local cold provocation test in non-pregnant females and in normotensive pregnant females (paired t test, p < 0.05). In hypertensive pregnant females HRV indices remained unchanged.
Our results indicate that the cardiovascular reactivity adaptation seen in normal pregnancy is absent in gestational hypertension.
妊娠高血压的病理生理学仍未被充分理解，尤其是在中枢自主神经系统控制和外周血管因素方面。
因此，我们的研究旨在同时调查健康未怀孕女性（N=12）、正常妊娠孕妇（N=16）和妊娠高血压孕妇（N=10）的血压、心率、心率变异性（HRV）和激光多普勒（LD）流量对局部冷却的反应。
与正常月经周期的未怀孕女性相比，正常妊娠孕妇的直接和间接 LD 流量对局部寒冷暴露的反应减弱（Dunnett 检验，p<0.05），但妊娠高血压孕妇的反应没有减弱。此外，仅在正常妊娠孕妇中，血压在寒冷暴露期间升高，心率在寒冷暴露期间降低，而在妊娠高血压孕妇中则没有（配对 t 检验，p<0.05）。同时计算的 HRV 总功率和 LF 功率值在未怀孕女性和正常妊娠孕妇中通常在局部寒冷激发试验期间增加（配对 t 检验，p<0.05）。在妊娠高血压孕妇中，HRV 指数保持不变。
我们的结果表明，正常妊娠中观察到的心血管反应适应性在妊娠高血压中缺失。
