Yvonne-Tee Get Bee, Rasool Aida Hanum Ghulam, Halim Ahmad Sukari, Rahman Abdul Rashid Abdul
Department of Pharmacology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kelantan.
Clin Hemorheol Microcirc. 2006;34(4):457-73.
Given that functional abnormalities of the microcirculation are one of the primary abnormalities in cardiovascular disease pathogenesis, various noninvasive clinical tools have been developed recently to assess the microvascular function, particularly at the skin. The common techniques used to assess cutaneous microvascular function in vivo include capillaroscopy, venous occlusion plethysmography, and laser-Doppler instruments (laser-Doppler fluximetry and laser-Doppler imaging). These noninvasive techniques can be used as an early measure of functional abnormalities within the microvascular tree, predominantly in population at high risk for cardiovascular events. This review discusses some underlying application principle of these techniques, including its clinical significance, method reproducibility and limitations.
鉴于微循环功能异常是心血管疾病发病机制中的主要异常之一，近年来已开发出各种非侵入性临床工具来评估微血管功能，尤其是皮肤微血管功能。用于体内评估皮肤微血管功能的常用技术包括毛细血管显微镜检查、静脉闭塞体积描记法和激光多普勒仪器（激光多普勒血流仪和激光多普勒成像）。这些非侵入性技术可作为微血管系统功能异常的早期测量方法，主要用于心血管事件高危人群。本综述讨论了这些技术的一些潜在应用原理，包括其临床意义、方法的可重复性和局限性。
