Division of Critical Care Neurology, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Neurocrit Care. 2010 Jun;12(3):390-4. doi: 10.1007/s12028-009-9323-8.
Low cerebrospinal fluid volume is typically diagnosed in patients presenting with positional headaches. However, severe intracranial hypotension and brain sagging may cause orthostatic coma. We present a case that illustrates this uncommon presentation.
Case report.
A 50-year-old man presented with orthostatic headaches and then developed bilateral subdural hematomas. Following unilateral subdural hematoma evacuation, the patient became gradually drowsier and more confused. Upon transfer to our hospital, he would become comatose each time he was placed in the upright position. Successful epidural patch at the level of a spontaneous cerebrospinal fluid leak documented by myelography resulted in complete resolution of his orthostatic symptoms despite reaccumulation of the subdural fluid collection.
Evacuation of subdural fluid collections may be detrimental in patients with low CSF volume by exacerbating the intracranial hypotension. Extreme brain sagging may lead to anatomical distortion of the diencephalon and brainstem resulting in coma.
低脑脊髓液量通常在出现体位性头痛的患者中诊断。然而,严重的颅内低血压和脑下垂可能导致直立性昏迷。我们呈现一个说明这种不常见表现的病例。
病例报告。
一名 50 岁男性出现体位性头痛,随后出现双侧硬脑膜下血肿。单侧硬脑膜下血肿清除后,患者逐渐变得昏昏欲睡和更加困惑。转至我们医院时,他每次处于直立位置都会昏迷。通过脊髓造影术确定自发性脑脊髓液漏的硬膜外贴补成功,尽管硬脑膜下液体积聚再次增加,但他的直立症状完全缓解。
在低脑脊髓液量的患者中,清除硬脑膜下积液可能会因加剧颅内低血压而有害。极度脑下垂可能导致间脑和脑干的解剖学扭曲,导致昏迷。