贝赫切特病的上消化道异常与幽门螺杆菌。

Upper gastrointestinal abnormalities and Helicobacter pylori in Behçet's disease.

机构信息

2nd Dermatology Clinic, Ankara Numune Education and Research Hospital, Ministry of Health, and General Surgery Department, Ankara University School of Medicine, Ankara, Turkey.

出版信息

Int J Dermatol. 2009 Nov;48(11):1174-6. doi: 10.1111/j.1365-4632.2009.04145.x.

DOI:10.1111/j.1365-4632.2009.04145.x

PMID:20064169

Abstract

BACKGROUND

There are few published clinical trials concerning upper gastrointestinal (GI) involvement in Behçet's disease (BD), and most have been performed on patients with upper GI tract symptoms.

AIM

We sought to determine whether routine endoscopy is indicated in asymptomatic patients with BD and whether Helicobacter pylori plays a role in the pathogenesis of BD.

METHODS

Forty consecutive patients with BD and 40 age- and gender-matched controls with tinea pedis were studied. All patients underwent fiberoptic esophagogastroduodenoscopy. Urea breath test was used to identify H. pylori.

RESULTS

Abnormalities were noted in 37 patients (93%): hiatal hernia (53%), antral gastritis (33%), pan-gastritis (23%), gastric ulceration (8%), and duodenal ulceration (8%). Helicobacter pylori was found in 26 patients (65%) with BD and in 28 controls (70%) (no significant difference by chi-squared test, P > 0.05). We found a high incidence of upper GI abnormalities in BD, but the abnormalities were not specific for the disorder.

CONCLUSIONS

Routine endoscopy and screening for H. pylori infection may not be necessary in asymptomatic patients with BD.

摘要

背景

关于白塞病（BD）上消化道（GI）受累的临床研究较少，且大多数研究都是针对上消化道症状患者进行的。

目的

我们旨在确定无症状 BD 患者是否需要常规内镜检查，以及幽门螺杆菌（H. pylori）是否在 BD 的发病机制中起作用。

方法

连续纳入 40 例 BD 患者和 40 例年龄、性别匹配的足癣对照者。所有患者均接受纤维胃镜检查。尿素呼气试验用于识别 H. pylori。

结果

37 例（93%）患者存在异常：膈疝（53%）、胃窦炎（33%）、全胃炎（23%）、胃溃疡（8%）和十二指肠溃疡（8%）。BD 患者中 H. pylori 阳性者 26 例（65%），对照组中阳性者 28 例（70%）（卡方检验无显著差异，P > 0.05）。我们发现 BD 患者上消化道异常发生率较高，但这些异常无特异性。