巴基斯坦 HIV 感染的注射吸毒者（IDUs）中存在“奠基者效应”的证据。
Evidence for a "Founder Effect" among HIV-infected injection drug users (IDUs) in Pakistan.
机构信息
Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
出版信息
BMC Infect Dis. 2010 Jan 12;10:7. doi: 10.1186/1471-2334-10-7.
BACKGROUND
We have previously reported a HIV-1 subtype A infection in a community of injection drug users (IDUs) in Karachi, Pakistan. We now show that this infection among the IDUs may have originated from a single source.
METHODS
Phylogenetic analysis was performed of partial gag sequences, generated using PCR, from 26 HIV-positive IDU samples.
RESULTS
Our results showed formation of a tight monophyletic group with an intra-sequence identity of < 98% indicating a "founder effect". Our data indicate that the HIV-1 epidemic in this community of IDUs may have been transmitted by an HIV positive overseas contract worker who admitted to having contact with commercial sex workers during stay abroad.
CONCLUSION
Specific measures need to implemented to control transmission of HIV infection in Pakistan through infected migrant workers.
背景
我们曾报道过在巴基斯坦卡拉奇的一个注射吸毒者（IDU）社区中发现的 HIV-1 亚型 A 感染。现在我们表明，这些 IDU 中的感染可能源自单一来源。
方法
使用 PCR 从 26 份 HIV 阳性 IDU 样本中生成了部分 gag 序列，并对其进行了系统发育分析。
结果
我们的结果表明，形成了一个紧密的单系群，序列内同一性<98%，表明存在“创始效应”。我们的数据表明，该 IDU 社区中的 HIV-1 流行可能是由一名承认在国外逗留期间与性工作者接触过的 HIV 阳性海外合同工传播的。
结论
需要通过受感染的移民工人实施具体措施来控制巴基斯坦的 HIV 感染传播。
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