Howard Hughes Medical Institute, University of Arizona, Tucson, 85721, USA.
Mol Cell. 2009 Dec 25;36(6):932-41. doi: 10.1016/j.molcel.2009.11.020.
The stress response in eukaryotic cells often inhibits translation initiation and leads to the formation of cytoplasmic RNA-protein complexes referred to as stress granules. Stress granules contain nontranslating mRNAs, translation initiation components, and many additional proteins affecting mRNA function. Stress granules have been proposed to affect mRNA translation and stability and have been linked to apoptosis and nuclear processes. Stress granules also interact with P-bodies, another cytoplasmic RNP granule containing nontranslating mRNA, translation repressors, and some mRNA degradation machinery. Together, stress granules and P-bodies reveal a dynamic cycle of distinct biochemical and compartmentalized mRNPs in the cytosol, with implications for the control of mRNA function.
真核细胞中的应激反应通常会抑制翻译起始，导致形成细胞质 RNA-蛋白质复合物，称为应激颗粒。应激颗粒包含非翻译的 mRNA、翻译起始组件和许多其他影响 mRNA 功能的蛋白质。应激颗粒被认为会影响 mRNA 的翻译和稳定性，并与细胞凋亡和核过程有关。应激颗粒还与 P 体相互作用，P 体是另一种含有非翻译 mRNA、翻译抑制剂和一些 mRNA 降解机制的细胞质 RNP 颗粒。应激颗粒和 P 体一起揭示了细胞质中不同生化和分隔的 mRNP 的动态循环，这对控制 mRNA 功能具有重要意义。
