加纳库马西地区疟疾与肠道蠕虫混合感染对生育结局的影响。
The effect of malaria and intestinal helminth coinfection on birth outcomes in Kumasi, Ghana.
机构信息
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
出版信息
Am J Trop Med Hyg. 2010 Jan;82(1):28-34. doi: 10.4269/ajtmh.2010.09-0165.
Abstract
This study was conducted to investigate the effect of Plasmodium falciparum and intestinal helminth coinfection on maternal anemia and birth outcomes. A cross-sectional study of 746 women who delivered in two hospitals in Kumasi was conducted. Data were collected using an investigator-administered questionnaire and from patients' medical records. Blood was collected for determination of P. falciparum and hemoglobin levels. Adverse pregnancy outcomes were high (44.6%). Coinfection (versus no infection) was associated with 3-fold increase in low birth weight. For women with anemia, coinfection was 2.6 times and 3.5 times as likely to result in preterm deliveries and small for gestational age infants. The odds of having anemia was increased almost 3-fold by coinfection. Coinfection (versus helminth only) resulted in increased risks of anemia, low birth weight, and small for gestational age infants. This study demonstrates that women with malaria and intestinal helminth coinfection are at particular risk of adverse birth outcomes.
摘要
本研究旨在探讨恶性疟原虫和肠道蠕虫混合感染对产妇贫血和分娩结局的影响。在库马西的两家医院进行了一项 746 名产妇的横断面研究。数据通过调查员管理的问卷和患者的病历收集。采集血液以确定恶性疟原虫和血红蛋白水平。不良妊娠结局发生率较高（44.6%）。混合感染（与无感染相比）与低出生体重的三倍增加相关。对于贫血妇女，混合感染导致早产和小于胎龄儿的风险增加 2.6 倍和 3.5 倍。混合感染使贫血的可能性增加了近 3 倍。与仅感染蠕虫相比，混合感染导致贫血、低出生体重和小于胎龄儿的风险增加。本研究表明，患有疟疾和肠道蠕虫混合感染的妇女尤其面临不良分娩结局的风险。
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