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Current treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.

作者信息

Fielding Adele K

出版信息

Haematologica. 2010 Jan;95(1):8-12. doi: 10.3324/haematol.2009.015974.

DOI:10.3324/haematol.2009.015974
PMID:20065078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2805747/
Abstract
摘要

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Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study.伊马替尼改善费城染色体阳性急性淋巴细胞白血病患者的早期无事件生存率：一项儿童肿瘤学组研究
J Clin Oncol. 2009 Nov 1;27(31):5175-81. doi: 10.1200/JCO.2008.21.2514. Epub 2009 Oct 5.
2
Concurrent intensive chemotherapy and imatinib before and after stem cell transplantation in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Final results of the CSTIBES02 trial.新诊断的费城染色体阳性急性淋巴细胞白血病患者在干细胞移植前后接受联合强化化疗和伊马替尼治疗。CSTIBES02 试验的最终结果。
Haematologica. 2010 Jan;95(1):87-95. doi: 10.3324/haematol.2009.011221. Epub 2009 Oct 1.
3
Philadelphia-positive patients who already harbor imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second- or third-line tyrosine kinase inhibitors.已经携带对伊马替尼耐药的Bcr-Abl激酶结构域突变的费城染色体阳性患者，发生与对二线或三线酪氨酸激酶抑制剂耐药相关的其他突变的可能性更高。
Blood. 2009 Sep 3;114(10):2168-71. doi: 10.1182/blood-2009-01-197186. Epub 2009 Jul 9.
4
Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL Trial MRC UKALLXII/ECOG2993.关于267例未经选择的费城染色体阳性成人急性淋巴细胞白血病患者的前瞻性结局数据证实，在伊马替尼时代之前，异基因移植优于化疗：来自国际ALL试验MRC UKALLXII/ECOG2993的结果。
Blood. 2009 May 7;113(19):4489-96. doi: 10.1182/blood-2009-01-199380. Epub 2009 Feb 24.
5
Prospective monitoring of BCR-ABL1 transcript levels in patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia undergoing imatinib-combined chemotherapy.对接受伊马替尼联合化疗的费城染色体阳性急性淋巴细胞白血病患者的BCR-ABL1转录水平进行前瞻性监测。
Br J Haematol. 2008 Nov;143(4):503-10. doi: 10.1111/j.1365-2141.2008.07377.x.
6
Allo-hematopoietic cell transplantation for Ph chromosome-positive ALL: impact of imatinib on relapse and survival.Ph染色体阳性急性淋巴细胞白血病的异基因造血细胞移植：伊马替尼对复发和生存的影响。
Bone Marrow Transplant. 2009 Jan;43(2):107-13. doi: 10.1038/bmt.2008.296. Epub 2008 Sep 8.
7
Long-term remission of Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation from matched sibling donors: a 20-year experience with the fractionated total body irradiation-etoposide regimen.来自匹配同胞供者的异基因造血细胞移植后费城染色体阳性急性淋巴细胞白血病的长期缓解：采用分次全身照射-依托泊苷方案的20年经验
Blood. 2008 Aug 1;112(3):903-9. doi: 10.1182/blood-2008-03-143115. Epub 2008 Jun 2.
8
Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation.成人急性淋巴细胞白血病患者的减低强度预处理异基因干细胞移植：来自欧洲血液与骨髓移植组的一项回顾性研究
Haematologica. 2008 Feb;93(2):303-6. doi: 10.3324/haematol.11960.
9
In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993).在标准风险的成人急性淋巴细胞白血病患者中，首次完全缓解时进行同胞全相合异基因移植获益最大，而自体移植在所有患者中均不如传统巩固/维持化疗有效：国际ALL试验（英国医学研究委员会UKALL XII/美国国立癌症研究所ECOG E2993）的最终结果。
Blood. 2008 Feb 15;111(4):1827-33. doi: 10.1182/blood-2007-10-116582. Epub 2007 Nov 29.
10
Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study.达沙替尼可使对伊马替尼耐药或不耐受的费城染色体阳性成人急性淋巴细胞白血病患者迅速获得血液学和细胞遗传学缓解：一项2期研究的中期结果。
Blood. 2007 Oct 1;110(7):2309-15. doi: 10.1182/blood-2007-02-073528. Epub 2007 May 11.