Jubelirer S J, Carper M, Farmer D E, Milroy S K, Parsons N C, Reynolds H R, Skaff K L
Cancer Care Center of Southern West Virginia, Charleston Area Medical Center.
W V Med J. 1991 Feb;87(2):57-60.
Although skin cancer screening is theoretically of value, its effectiveness has not been firmly established because few studies have systematically followed persons with a positive screen to obtain pathologically confirmed diagnoses. From the 799 persons screened at Charleston Area Medical Center in 1988 and 1989, 153 screenees with suspected skin cancer, dysplastic nevi, and congenital nevi were followed to determine their final diagnosis. Follow-up was done by letter and telephone calls to both the individuals who screened positive and their treating physicians. Eighty-four (54 percent) then sought medical attention as a result of letters and calls. Thirty-one basal cell carcinomas, three squamous cell carcinomas, three dysplastic nevi, two melanomas, and one congenital nevus were pathologically confirmed. The predictive value positive of the screenings was 32 percent to 60 percent for non-melanoma skin cancer, 9 percent to 25 percent for dysplastic nevi, and 15 percent for melanoma. This study suggests that post-screening follow-up of those with suspected premalignant and malignant skin lesions is feasible and should be encouraged so that more definitive evaluation and treatment can potentially be performed and skin cancer screenings more accurately assessed.
尽管皮肤癌筛查理论上具有价值，但其有效性尚未得到确凿证实，因为很少有研究系统地跟踪筛查结果呈阳性的人以获得病理确诊。在1988年和1989年于查尔斯顿地区医疗中心接受筛查的799人中，对153名疑似患有皮肤癌、发育异常痣和先天性痣的受检者进行了跟踪，以确定他们的最终诊断。通过给筛查呈阳性的个体及其治疗医生写信和打电话进行随访。其中84人（54%）因信件和电话而寻求医疗帮助。病理确诊了31例基底细胞癌、3例鳞状细胞癌、3例发育异常痣、2例黑色素瘤和1例先天性痣。非黑色素瘤皮肤癌筛查的阳性预测值为32%至60%，发育异常痣为9%至25%，黑色素瘤为15%。这项研究表明，对疑似皮肤癌前病变和恶性病变的受检者进行筛查后随访是可行的，应予以鼓励，以便有可能进行更明确的评估和治疗，并更准确地评估皮肤癌筛查。
