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本文引用的文献

1
Motavizumab, a second-generation humanized mAb for the prevention of respiratory syncytial virus infection in high-risk populations.莫他维izumab，一种用于预防高危人群呼吸道合胞病毒感染的第二代人源化单克隆抗体。
Curr Opin Mol Ther. 2009 Apr;11(2):208-18.
2
Safety, tolerability, pharmacokinetics, and immunogenicity of motavizumab, a humanized, enhanced-potency monoclonal antibody for the prevention of respiratory syncytial virus infection in at-risk children.莫他维izumab的安全性、耐受性、药代动力学及免疫原性研究，莫他维izumab是一种人源化、高效单克隆抗体，用于预防高危儿童呼吸道合胞病毒感染。
Pediatr Infect Dis J. 2009 Apr;28(4):267-72. doi: 10.1097/INF.0b013e31818ffd03.
3
Immunoprophylaxis of RSV infection: advancing from RSV-IGIV to palivizumab and motavizumab.呼吸道合胞病毒感染的免疫预防：从呼吸道合胞病毒免疫球蛋白静脉注射剂发展到帕利珠单抗和莫他珠单抗。
Curr Top Microbiol Immunol. 2008;317:103-23. doi: 10.1007/978-3-540-72146-8_4.
4
Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract.莫他维izumab的研发，一种用于预防上、下呼吸道呼吸道合胞病毒感染的超高效抗体。
J Mol Biol. 2007 May 4;368(3):652-65. doi: 10.1016/j.jmb.2007.02.024. Epub 2007 Feb 20.
5
Comparative effects of two neutralizing anti-respiratory syncytial virus (RSV) monoclonal antibodies in the RSV murine model: time versus potency.两种中和抗呼吸道合胞病毒（RSV）单克隆抗体在RSV小鼠模型中的比较效果：时间与效力。
Antimicrob Agents Chemother. 2005 Nov;49(11):4700-7. doi: 10.1128/AAC.49.11.4700-4707.2005.
6
Ultra-potent antibodies against respiratory syncytial virus: effects of binding kinetics and binding valence on viral neutralization.针对呼吸道合胞病毒的超高效抗体：结合动力学和结合价对病毒中和作用的影响
J Mol Biol. 2005 Jul 1;350(1):126-44. doi: 10.1016/j.jmb.2005.04.049.
7
Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus.一种对呼吸道合胞病毒具有强大体外和体内活性的人源化单克隆抗体（MEDI-493）的研发。
J Infect Dis. 1997 Nov;176(5):1215-24. doi: 10.1086/514115.
8
Aerosolized ribavirin treatment of infants with respiratory syncytial viral infection. A randomized double-blind study.雾化吸入利巴韦林治疗呼吸道合胞病毒感染婴儿。一项随机双盲研究。
N Engl J Med. 1983 Jun 16;308(24):1443-7. doi: 10.1056/NEJM198306163082403.

莫他赛珠单抗。

Motavizumab.

机构信息

Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.

出版信息

MAbs. 2009 Sep-Oct;1(5):439-42. doi: 10.4161/mabs.1.5.9496. Epub 2009 Sep 10.

DOI:10.4161/mabs.1.5.9496
PMID:20065632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2759493/
Abstract

Motavizumab (MEDI-524, Numax) is a second generation monoclonal antibody (mAb) derived from palivizumab (Synagis) using affinity maturation techniques. Motavizumab is currently undergoing US Food and Drug Administration review as a treatment for respiratory syncytial virus (RSV) prophylaxis. It has been evaluated in large-scale clinical studies, and has demonstrated efficacy in reducing the disease burden of RSV in high-risk infant populations.

摘要

莫达珠单抗（MEDI-524，Numax）是第二代单克隆抗体（mAb），使用亲和力成熟技术从帕利珠单抗（Synagis）衍生而来。莫达珠单抗目前正在接受美国食品和药物管理局的审查，作为治疗呼吸道合胞病毒（RSV）预防的药物。它已经在大规模临床研究中进行了评估，并证明了在降低高危婴儿人群 RSV 疾病负担方面的疗效。