细胞毒性T细胞和调节性T细胞在复发/难治性霍奇金淋巴瘤中的作用。
The role of cytotoxic and regulatory T cells in relapsed/refractory Hodgkin lymphoma.
作者信息
Koreishi Aashiyana F, Saenz Adam J, Persky Dan O, Cui Hayan, Moskowitz Allison, Moskowitz Craig H, Teruya-Feldstein Julie
机构信息
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
出版信息
Appl Immunohistochem Mol Morphol. 2010 May;18(3):206-11. doi: 10.1097/PAI.0b013e3181c7138b.
Abstract
Recent data suggests the presence of cytotoxic (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) in classical Hodgkin lymphoma (cHL) tissues has been shown to correlate with poor overall survival in mainly diagnostic biopsies. By tissue microarray analyses, we extend this observation to a cohort of relapsed/refractory cHL tissue biopsies and analyze immunohistochemical expression of FOXP3, TIA-1, and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) correlated with poor overall survival (P<0.0001), low expression of FOXP3 (<25%) correlated with poor overall survival (P<0.01), and combined high TIA-1 (>50%) and low FOXP3 (<25%) correlated with poor overall survival (P<0.0001). Expression of cytotoxic and regulatory T-cells shows prognostic significance in the relapsed/refractory clinical setting of cHL.
摘要
近期数据表明，在经典型霍奇金淋巴瘤（cHL）组织中，细胞毒性T细胞（TIA-1和颗粒酶B阳性）和调节性T细胞（FOXP3阳性）的存在已被证明与主要诊断活检中的总体生存率较差相关。通过组织微阵列分析，我们将这一观察结果扩展至一组复发/难治性cHL组织活检，并分析了炎症背景和肿瘤微环境中FOXP3、TIA-1和颗粒酶B的免疫组化表达。TIA-1高表达（>50%）与总体生存率较差相关（P<0.0001），FOXP3低表达（<25%）与总体生存率较差相关（P<0.01），而TIA-1高表达（>50%）和FOXP3低表达（<25%）共同出现则与总体生存率较差相关（P<0.0001）。细胞毒性T细胞和调节性T细胞的表达在cHL的复发/难治性临床环境中具有预后意义。
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