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肾素-血管紧张素系统作为细胞容积的调节因子。对心肌缺血的影响。

Renin Angiotensin system as a regulator of cell volume. Implications to myocardial ischemia.

作者信息

De Mello Walmor C

机构信息

Medical Sciences Campus, School of Medicine, UPR, San Juan, PR 00936-5067, USA.

出版信息

Curr Cardiol Rev. 2009 Jan;5(1):65-8. doi: 10.2174/157340309787048149.

DOI:10.2174/157340309787048149
PMID:20066151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2803291/
Abstract

It is known that long lasting changes in cell volume are incompatible with cellular functions. In the present review, I discussed the role of cell volume on gene expression and protein synthesis as well as the importance of the renin angiotensin system on the regulation of cell volume in the failing heart. Moreover, the relationship between mechanical stretch, cell volume and the renin angiotensin system as well some translational studies are also described and their relevance to the prevention or reduction of cardiac damage during myocardial ischemia is emphasized.

摘要

众所周知，细胞体积的长期变化与细胞功能不相容。在本综述中，我讨论了细胞体积在基因表达和蛋白质合成中的作用，以及肾素血管紧张素系统在衰竭心脏中调节细胞体积的重要性。此外，还描述了机械牵张、细胞体积与肾素血管紧张素系统之间的关系以及一些转化研究，并强调了它们与预防或减少心肌缺血期间心脏损伤的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98fc/2803291/6d955e5a8891/CCR-5-65_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98fc/2803291/6d955e5a8891/CCR-5-65_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98fc/2803291/6d955e5a8891/CCR-5-65_F1.jpg

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Mechanisms and significance of cell volume regulation.细胞体积调节的机制及意义
J Am Coll Nutr. 2007 Oct;26(5 Suppl):613S-623S. doi: 10.1080/07315724.2007.10719667.
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Cell volume regulation in cardiac myocytes: a leaky boat gets a new bilge pump.
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The hepatocyte integrin system and cell volume sensing.肝细胞整合素系统与细胞体积感知。
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Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.机械应力可激活1型血管紧张素II受体，而无需血管紧张素II的参与。
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