Department of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, 120-752 Seoul, South Korea.
World J Gastroenterol. 2010 Jan 14;16(2):256-63. doi: 10.3748/wjg.v16.i2.256.
To evaluate the epidemiologic features of young age gastric cancer (GC).
Retrospectively, a total of 3242 patients with GC between 18 and 45 years of age and 3000 sex- and age-matched controls were reviewed. All subjects were stratified into 3 groups based on age (A, 18-30 years; B, 31-40 years; C, 41-45 years). Epidemiologic characteristics and risk factors were investigated with reference to their age and gender.
Compared to controls, more frequent intake of high risk diet (P = 0.00075), history of heavy smoking (P = 0.00087), intake of heavy alcohol (P = 0.00091), lower social economic status (P = 0.00083), body mass index > 30 (P = 0.00097), urban residence (P = 0.00065), and more frequent exposure to harmful occupational environments (P = 0.00072) were observed in all age groups and both genders in young age GC. These relationships were weaker in females compared to males of the same age, and were stronger as the age of patients increased. However, in group C of young age GC patients, environmental factors played important roles in females and males with a similar body weight. In females, older age at first delivery (> 35 years), lack of lactation history, nulliparity, and poor nutritional status during pregnancy were significantly associated with an increased risk of GC (P = 0.00034). In this study, 252 patients (7.8%) had a family history of GC with high odds ratio (OR) (3.22-4.21). In particular, family history was more closely associated with GC in males (OR, 4.21 in male vs 3.46 in female) and more advanced cases (P = 0.00051).
Hormonal associated factors were more commonly associated with females whereas environmental factors were more commonly associated with males in young age GC patients.
评估青年胃癌（GC）的流行病学特征。
回顾性分析了 3242 例年龄在 18-45 岁的青年 GC 患者和 3000 名年龄、性别匹配的对照者。所有患者均根据年龄分为 3 组（A 组，18-30 岁；B 组，31-40 岁；C 组，41-45 岁）。参考年龄和性别，调查了流行病学特征和危险因素。
与对照组相比，各年龄段和性别组的青年 GC 患者均有更高的高危饮食摄入（P = 0.00075）、重度吸烟史（P = 0.00087）、重度饮酒史（P = 0.00091）、社会经济地位较低（P = 0.00083）、体重指数（BMI）>30（P = 0.00097）、城市居住（P = 0.00065）和更多接触有害职业环境（P = 0.00072）。与同年龄的男性相比，女性这些关系较弱，且随着患者年龄的增长而增强。然而，在青年 GC 患者 C 组中，环境因素在体重相似的女性和男性中发挥了重要作用。在女性中，初产年龄较大（>35 岁）、缺乏哺乳史、未婚和妊娠期间营养状况差与 GC 风险增加显著相关（P = 0.00034）。本研究中，252 例（7.8%）患者有 GC 家族史，其比值比（OR）较高（3.22-4.21）。特别是，家族史与男性（OR，男性 4.21 对女性 3.46）和更晚期病例（P = 0.00051）更密切相关。
青年 GC 患者中，激素相关因素与女性更相关，而环境因素与男性更相关。
