[乳香中的西松烯二萜类化合物]
[Cembrane diterpenes in olibanum].
作者信息
Wang Feng, Li Zhanlin, Liu Tao, Hua Huiming
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2009 Oct;34(19):2477-80.
OBJECTIVE
To study the constituents in the chloroform extract of olibanum and their antitumor activities.
METHOD
The compounds were isolated by chromatographic methods and their structures were identified on the basis of spectroscopic methods and X-ray diffraction. The antiproliferative effect of the compounds in human leukemia HL-60 cells was tested by viable cell counting.
RESULT
Four cembrane diterpenes were isolated and identified as incensole-oxide (1), acetyl incensole-oxide (2), incensole (3), and acetyl incensole (4).
CONCLUSION
Compounds 2 and 4 were isolated from the genus Boswellia for the first time. Compound 4 showed growth inhibitory effect against human leukemia HL-60 cell lines with IG50 value of (16.3 +/- 3.4) micromol x L(-1).
目的
研究乳香氯仿提取物中的成分及其抗肿瘤活性。
方法
采用色谱法分离化合物，并基于光谱法和X射线衍射鉴定其结构。通过活细胞计数检测化合物对人白血病HL - 60细胞的抗增殖作用。
结果
分离鉴定出4种松香烷二萜，分别为氧化白菖烯（1）、乙酰氧化白菖烯（2）、白菖烯（3）和乙酰白菖烯（4）。
结论
化合物2和4首次从乳香属中分离得到。化合物4对人白血病HL - 60细胞系具有生长抑制作用，IG50值为（16.3±3.4）μmol·L⁻¹ 。
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