来自长圆叶巴豆的新半日花烷二萜类化合物。

New halimane diterpenoids from Croton oblongifolius.

作者信息

Roengsumran Sophon, Pornpakakul Surachai, Muangsin Nongnuj, Sangvanich Polkit, Nhujak Thumnoon, Singtothong Pravit, Chaichit Narongsak, Puthong Songchan, Petsom Amorn

机构信息

Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.

出版信息

Planta Med. 2004 Jan;70(1):87-9. doi: 10.1055/s-2004-815466.

DOI:10.1055/s-2004-815466

PMID:14765304

Abstract

Three new halimane-type diterpenoids, crotohalimaneic acid ( 1), crotohalimoneic acid ( 2) and 12-benzoyloxycrotohalimaneic acid ( 3), were isolated from the stem bark of Croton oblongifolius Roxb. Their structures were established on the basis of spectroscopic and X-ray analysis. Compounds 1 and 2 showed non-specific strong cytotoxicity against a panel of human tumor cell lines; whereas 3 was inactive.

摘要

从长圆叶巴豆（Croton oblongifolius Roxb.）的茎皮中分离出三种新的半日花烷型二萜类化合物，巴豆半日花酸（1）、巴豆半日花酮酸（2）和12-苯甲酰氧基巴豆半日花酸（3）。它们的结构通过光谱和X射线分析得以确定。化合物1和2对一组人类肿瘤细胞系表现出非特异性的强细胞毒性；而化合物3没有活性。