海州常山中的生物活性二萜类化合物。

Bioactive diterpenes from Clerodendrum kaichianum.

作者信息

Xu Mingfeng, Shen Lianqing, Wang Kuiwu, Du Qizhen, Wang Nan

机构信息

College of Food Science and Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou 310035, China.

出版信息

Nat Prod Commun. 2011 Jan;6(1):3-5.

PMID:21366034

Abstract

Bioassay-guided isolation studies of the extract of Clerodendrum kaichianum Hsu., a new rearranged abietane diterpene and five known diterpene compounds were isolated by various chromatography methods. Their structures were identified by means of spectroscopic methods, including 1D- and 2D-NMR spectroscopy, as (16R)-12,16-epoxy-11,14,17-trihydroxy-17(15-->16)-abeo-8,11,13-abietatrien-7-one (1), villosin A (2), salvinolone (3), 14-deoxyloleon U (4), 5,6-dehydrosugiol (5), and coleon U (6). Compounds 1, 2, 3, and 5 are reported for the first time for this genus. Compounds 1, 2, and 6 demonstrated potent cytotoxic activities against the HL-60 tumor cell line.

摘要

对海州常山提取物进行生物活性导向的分离研究，通过各种色谱方法分离得到一种新的重排枞烷二萜和五种已知的二萜化合物。通过光谱方法，包括一维和二维核磁共振光谱，确定它们的结构分别为(16R)-12,16-环氧-11,14,17-三羟基-17(15→16)-去甲-8,11,13-枞三烯-7-酮(1)、绒毛素A(2)、鼠尾草酮(3)、14-脱氧来洛醇U(4)、5,6-脱水苏吉醇(5)和科伦醇U(6)。化合物1、2、3和5首次在该属中被报道。化合物1、2和6对HL-60肿瘤细胞系表现出强大的细胞毒活性。