Hughes Amanda, Rando Oliver J
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street No, 903, Worcester, MA 01605, USA.
J Biol. 2009;8(11):96. doi: 10.1186/jbiol207. Epub 2009 Dec 23.
The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic thermodynamic preference of a given sequence in the yeast genome for the histone octamer can largely be captured with a simple model, and in fact is mostly explained by %GC. Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed. See research article http://www.biomedcentral.com/1471-2105/10/442.
基因组序列在指导真核生物基因组包装成染色质过程中的作用，一直是近期相当多争论的主题。蒂洛和休斯的一篇新论文表明，酵母基因组中给定序列对组蛋白八聚体的内在热力学偏好，在很大程度上可以用一个简单模型来捕捉，实际上主要由%GC来解释。因此，从基因组序列预测核小体占据率的规则比声称的要简单得多。见研究文章http://www.biomedcentral.com/1471-2105/10/442 。
