Dipartimento di Oncologia Sperimentale ed Applicazioni Cliniche, Section of Endocrinology, University of Palermo, Palermo, Italy.
Diabetes Care. 2010 Apr;33(4):920-2. doi: 10.2337/dc09-1825. Epub 2010 Jan 12.
To individuate a novel sex-specific index, based on waist circumference, BMI, triglycerides, and HDL cholesterol, indirectly expressing visceral fat function.
Visceral adiposity index (VAI) was first modeled on 315 nonobese healthy subjects. Using two multiple logistic regression models, VAI was retrospectively validated in 1,498 primary care patients in comparison to classical cardio- and cerebrovascular risk factors.
All components of metabolic syndrome increased significantly across VAI quintiles. VAI was independently associated with both cardiovascular (odd ratio [OR] 2.45; 95% CI 1.52-3.95; P < 0.001) and cerebrovascular (1.63; 1.06-2.50; P = 0.025) events. VAI also showed significant inverse correlation with insulin sensitivity during euglycemic-hyperinsulinemic clamp in a subgroup of patients (R(s) = -0.721; P < 0.001). By contrast, no correlations were found for waist circumference and BMI.
Our study suggests VAI is a valuable indicator of "visceral adipose function" and insulin sensitivity, and its increase is strongly associated with cardiometabolic risk.
基于腰围、BMI、甘油三酯和 HDL 胆固醇，确定一个新的性别特异性指数，间接表达内脏脂肪功能。
首先在 315 名非肥胖健康受试者中建立了内脏脂肪指数（VAI）模型。使用两个多元逻辑回归模型，将 VAI 与经典的心血管和脑血管危险因素进行比较，在 1498 名初级保健患者中进行回顾性验证。
代谢综合征的所有成分在 VAI 五分位组中均显著增加。VAI 与心血管疾病（比值比 [OR] 2.45；95%置信区间 1.52-3.95；P<0.001）和脑血管疾病（1.63；1.06-2.50；P=0.025）事件均独立相关。在患者亚组的葡萄糖正常高胰岛素钳夹试验中，VAI 与胰岛素敏感性呈显著负相关（R(s)=-0.721；P<0.001）。相比之下，腰围和 BMI 与 VAI 无相关性。
本研究表明，VAI 是“内脏脂肪功能”和胰岛素敏感性的一个有价值的指标，其增加与心血管代谢风险密切相关。
