Nephrology Department, IASIO Hospital - General Clinic of Kallithea, Athens, Greece.
Blood Purif. 2010;29(3):274-9. doi: 10.1159/000274462.
BACKGROUND/AIMS: Aims of the present study are to examine the effects of atorvastatin administration and the influence of membrane flux on adhesion molecules expression on monocytes.
We studied CD11b, CD18 and CD62L expression on monocytes (flow cytometry) in 32 patients, 16 on low-flux (LFD) and 16 on high-flux (HFD) polysulfone hemodialysis, before and after dialysis and also after administration of atorvastatin 20 mg/day for 6 months.
After hemodialysis, expression of CD11b and CD18 increased and expression of CD62L decreased. After atorvastatin administration there was a decrease in pre-dialysis monocyte expression of CD11b and CD18, and an increase in the expression of CD62L compared to pre-dialysis baseline values. There were no statistically significant differences in expression of all three molecules between LFD and HFD groups.
Polysulfone dialysis process activates monocytes irrespectively of the membrane flux. Atorvastatin use is associated with reduced monocyte activation.
背景/目的：本研究旨在探讨阿托伐他汀给药和膜通量对单核细胞黏附分子表达的影响。
我们研究了 32 名患者单核细胞（流式细胞术）中 CD11b、CD18 和 CD62L 的表达，这些患者分别接受低通量（LFD）和高通量（HFD）聚砜血液透析，在透析前后以及阿托伐他汀 20mg/天给药 6 个月后。
血液透析后，CD11b 和 CD18 的表达增加，CD62L 的表达减少。阿托伐他汀给药后，与透析前基线值相比，CD11b 和 CD18 的单核细胞表达减少，CD62L 的表达增加。LFD 和 HFD 两组之间所有三种分子的表达均无统计学差异。
聚砜透析过程无论膜通量如何都会激活单核细胞。阿托伐他汀的使用与单核细胞的激活减少有关。
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