阿托伐他汀对正常胆固醇血症冠心病患者白细胞细胞黏附分子的影响。
Effect of atorvastatin on cellular adhesion molecules on leukocytes in patients with normocholesterolemic coronary artery disease.
机构信息
University Medical Centre Mannheim, First Department of Medicine, D-68167 Mannheim, Germany.
出版信息
In Vivo. 2010 Mar-Apr;24(2):189-93.
BACKGROUND
Expression of cellular adhesion molecules on leukocytes plays a key role in coronary artery disease (CAD). The aim of the present study was to assess whether atorvastatin therapy has an impact on the expression of cellular adhesion molecules on leukocytes in patients with normocholesterolemic CAD.
PATIENTS AND METHODS
In 54 patients with CAD and atorvastatin treatment and 54 CAD patients without atorvastatin therapy, expression of CD40L, CD11a, CD11b, CD54, CD62L and CD41 on leukocytes was measured using flow cytometry. All patients were normocholesterolemic.
RESULTS
Atorvastatin treatment led to a significantly lower expression of CD40L, CD11b and CD54 on monocytes (p<0.05) and neutrophils (p<0.05). Expression of CD11a was significantly lower on monocytes (p<0.05) in atorvastatin-treated patients.
CONCLUSION
The present results indicate that atorvastatin apparently improves chronic inflammation and may have a beneficial effect on hemostasis by reducing the expression of cellular adhesion molecules on leukocytes.
背景
白细胞表面细胞黏附分子的表达在冠状动脉疾病（CAD）中起着关键作用。本研究旨在评估阿托伐他汀治疗是否会影响正常胆固醇 CAD 患者白细胞表面细胞黏附分子的表达。
方法
在 54 例接受阿托伐他汀治疗的 CAD 患者和 54 例未接受阿托伐他汀治疗的 CAD 患者中，使用流式细胞术检测白细胞表面 CD40L、CD11a、CD11b、CD54、CD62L 和 CD41 的表达。所有患者的胆固醇均正常。
结果
阿托伐他汀治疗导致单核细胞（p<0.05）和中性粒细胞（p<0.05）上 CD40L、CD11b 和 CD54 的表达显著降低。阿托伐他汀治疗组单核细胞上 CD11a 的表达显著降低（p<0.05）。
结论
本研究结果表明，阿托伐他汀可明显改善慢性炎症，通过降低白细胞表面细胞黏附分子的表达，可能对止血产生有益影响。
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