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1 年维持性训练对 COPD 患者身体机能和健康状况的长期影响:一项随机对照研究。

Long-term effects of 1-year maintenance training on physical functioning and health status in patients with COPD: A randomized controlled study.

机构信息

Department of Cardiology and Respiratory Medicine, University Hospital of Copenhagen, Hvidovre, Denmark.

出版信息

J Cardiopulm Rehabil Prev. 2010 Jan-Feb;30(1):47-52. doi: 10.1097/HCR.0b013e3181c9c985.

DOI:10.1097/HCR.0b013e3181c9c985
PMID:20068423
Abstract

PURPOSE

To examine whether maintenance training (MT) for 1 year improved the long-term effects of a 7-week chronic obstructive pulmonary disease (COPD) rehabilitation program.

METHODS

After a 7-week outpatient rehabilitation program, 96 patients with COPD were randomized to either an MT group (n = 55) or a control group (n = 41). Both groups were requested to continue unsupervised training at home. The MT group received weekly supervised training the first 6 months, supervised training every second week the next 6 months, and finally no supervised training the last 6 months of the 18-month study period. Primary effect parameters were Endurance Shuttle Walk Test (ESWT) time and health status (St. George's Respiratory Questionnaire, SGRQ). Secondary effect parameters were adherence to supervised training, dropout rates, and hospitalization.

RESULTS

Compared with the control group, the MT group had significantly better ESWT times at 3 and 6 months (+43.9 seconds; P= .03, and +75.1 seconds; P= .02) and insignificantly higher ESWT time at 12 months (+66.6 seconds; P= .40). SGRQ total score declined gradually after the 7-week program with no difference between the 2 groups, and after 18 months, the score was 1.7 units (95% confidence interval: -0.7 to 4.1) worse than at randomization. There was no difference between the 2 groups regarding dropout rates or hospitalization.

DISCUSSION

Weekly MT for 12 months improved walking time but had no influence on health-related quality of life or hospital admissions, compared with unsupervised daily training at home. The effect of the MT was closely related to adherence to the program.

摘要

目的

探讨为期 1 年的维持性训练(MT)是否能改善为期 7 周的慢性阻塞性肺疾病(COPD)康复计划的长期效果。

方法

在 7 周的门诊康复计划后,96 例 COPD 患者被随机分为 MT 组(n = 55)或对照组(n = 41)。两组均被要求在家中进行非监督训练。MT 组在前 6 个月每周接受一次监督训练,第 7 至 12 个月每两周接受一次监督训练,最后在 18 个月的研究期间的最后 6 个月内不再接受监督训练。主要效果参数为耐力穿梭步行测试(ESWT)时间和健康状况(圣乔治呼吸问卷,SGRQ)。次要效果参数为监督训练的依从性、脱落率和住院率。

结果

与对照组相比,MT 组在 3 个月和 6 个月时 ESWT 时间明显更长(分别增加 43.9 秒;P=.03,和增加 75.1 秒;P=.02),在 12 个月时 ESWT 时间略长(增加 66.6 秒;P=.40)。7 周康复计划后,SGRQ 总分逐渐下降,两组间无差异,18 个月后,总分比随机分组时差 1.7 分(95%置信区间:-0.7 至 4.1)。两组的脱落率或住院率无差异。

讨论

与在家中进行非监督的日常训练相比,为期 12 个月的每周 MT 可改善步行时间,但对健康相关生活质量或住院无影响。MT 的效果与对该方案的依从性密切相关。

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