诱导老龄、高血压、糖尿病大鼠发生中风。
Inducing stroke in aged, hypertensive, diabetic rats.
机构信息
National Stroke Research Institute and University of Melbourne Department of Medicine, Austin Health, Heidelberg, Victoria, Australia.
出版信息
J Cereb Blood Flow Metab. 2010 Apr;30(4):729-33. doi: 10.1038/jcbfm.2009.273. Epub 2010 Jan 13.
Abstract
Animal models of ischemic stroke often neglect comorbidities common in patients. This study shows the feasibility of inducing stroke by 2 h of thread occlusion of the middle cerebral artery in aged (56 week old) spontaneously hypertensive rats (SHRs) with both acute (2 weeks) and chronic (36 weeks) diabetes. After modifying the streptozotocin dosing regimen to ensure that old SHRs survived the induction of diabetes, few died after induction of stroke. Induction of stroke is feasible in rats with multiple comorbidities. Inclusion of such comorbid animals may improve translation from the research laboratory to the clinic.
摘要
缺血性中风的动物模型通常忽略了患者中常见的合并症。本研究显示了通过 2 小时的线栓阻塞大脑中动脉在老年（56 周龄）自发性高血压大鼠（SHR）中诱导中风的可行性，同时伴有急性（2 周）和慢性（36 周）糖尿病。在修改链脲佐菌素给药方案以确保老年 SHR 在诱导糖尿病后存活后，很少有大鼠在诱导中风后死亡。患有多种合并症的大鼠可以成功诱导中风。纳入这些合并症动物可能会提高从研究实验室到临床的转化效果。
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