Bach D E, Burgess L P, Zislis T, Quigley N, Hollinger J O
United States Army Institute of Dental Research, Walter Reed Army Institute of Research, Washington, DC.
Arch Otolaryngol Head Neck Surg. 1991 Apr;117(4):390-5. doi: 10.1001/archotol.1991.01870160044006.
Both autogenous bone grafts and demineralized freeze-dried allogeneic bone implants were evaluated for mandibular reconstruction. Four-centimeter segmental defects of the midbody of the edentulous mandible were reconstructed in 36 dogs, with specimens recovered at 3 and 6 months and quantitatively compared for total and new bone by histomorphometric analysis. Autogenous grafts consisted of corticocancellous cranial block (CB), corticocancellous iliac block (IB), and particulate cancellous iliac marrow (PM). The allogeneic bone was demineralized and freeze-dried, and consisted of particulate cortical endochondral bone (FP), cranial cortical block (FCB), and iliac cortical block (FIB). Clinically and histomorphometrically, results appeared to indicate that (1) CB compared favorably with IB at 3 and 6 months for total bone, but IB showed a trend for more new bone formation at 6 months, a trend that may be due to the thicker cortical component of CB, which requires longer time periods to remodel than the cancellous rich IB; (2) FP failed to achieve bony union at 3 months, with inadequate rates of new bone formation; and (3) FCB and FIB compared favorably for total bone with CB and IB at 6 months, although new bone for autogenous CB and IB was 26.9% and 45.4%, while new bone for allogeneic FCB and FIB represented only 7.9% and 17.4%.
对自体骨移植和脱矿冻干同种异体骨植入物进行了下颌骨重建评估。在36只犬中重建了无牙下颌骨体部4厘米的节段性缺损，分别在3个月和6个月时回收标本，并通过组织形态计量分析对总骨量和新骨量进行定量比较。自体移植物包括皮质松质颅骨块（CB）、皮质松质髂骨块（IB）和颗粒状松质髂骨髓（PM）。同种异体骨经过脱矿和冻干处理，包括颗粒状皮质软骨内骨（FP）、颅骨皮质块（FCB）和髂骨皮质块（FIB）。临床和组织形态计量学结果似乎表明：（1）在3个月和6个月时，CB在总骨量方面与IB相当，但IB在6个月时有更多新骨形成的趋势，这种趋势可能是由于CB的皮质成分较厚，与富含松质骨的IB相比，需要更长时间进行重塑；（2）FP在3个月时未能实现骨愈合，新骨形成率不足；（3）在6个月时，FCB和FIB在总骨量方面与CB和IB相当，尽管自体CB和IB的新骨分别占26.9%和45.4%，而同种异体FCB和FIB的新骨仅占7.9%和17.4%。
