Department of Psychiatry and Behavioral Science, Medical University of South Carolina in Charleston, USA.
Psychiatry. 2009 Winter;72(4):360-9. doi: 10.1521/psyc.2009.72.4.360.
Tobacco smoking has been found to increase after the experience of a traumatic event and has been associated with posttraumatic stress disorder (PTSD). Initiation and persistence of cigarette smoking is moderately heritable; two recent investigations have implicated the COMT Val158Met (also known as rs4680) polymorphism in smoking age of initiation, dependence, as well as in quantity and frequency of smoking. To examine a possible association of COMT Val158Met and posttrauma increases in cigarette smoking, we studied 614 adults from the 2004 Florida Hurricane Study who returned saliva DNA samples via mail. PTSD was strongly associated with increased smoking. Moreover, each COMT Val158Met 'Met' allele predicted a 2.10-fold risk of smoking post-hurricane, independent of PTSD; follow-up analyses revealed that this finding was primarily driven by European-American males. This study represents the first genetic association study (to our knowledge) of smoking behavior following an acute stressor.
吸烟行为与创伤后应激障碍（PTSD）有关，研究发现经历创伤性事件后人们会增加吸烟量。吸烟的起始和持续存在具有中度遗传性；最近的两项研究表明，COMT Val158Met（也称为 rs4680）多态性与吸烟起始年龄、依赖性以及吸烟量和频率有关。为了研究 COMT Val158Met 与创伤后吸烟增加之间是否存在关联，我们对 2004 年佛罗里达飓风研究中的 614 名成年人进行了研究，这些成年人通过邮件寄回了唾液 DNA 样本。PTSD 与吸烟量增加呈强相关。此外，COMT Val158Met 的每个“Met”等位基因预测了飓风后吸烟的风险增加 2.10 倍，与 PTSD 无关；后续分析表明，这一发现主要由欧洲裔美国男性驱动。这项研究是我们所知的第一个针对急性应激源后吸烟行为的遗传关联研究。
