儿茶酚-O-甲基转移酶与白细胞介素6基因多态性与创伤后应激障碍的关联

The Association of Catechol-O-Methyl-Transferase and Interleukin 6 Gene Polymorphisms with Posttraumatic Stress Disorder.

作者信息

Haxhibeqiri Valdete, Haxhibeqiri Shpend, Topciu-Shufta Valdete, Agani Ferid, Goci Uka Aferdita, Hoxha Blerina, Dzubur Kulenovic Alma, Jakovljević Miro, Avdibegović Esmina, Kravić Nermina, Muminović Umihanić Mirnesa, Sinanović Osman, Šabić Džananović Emina, Kučukalić Abdulah, Kučukalić Sabina, Bravo Mehmedbašić Alma, Aukst Margetić Branka, Jakšić Nenad, Cima Franc Ana, Rudan Duško, Pavlović Marko, Babić Romana, Ferić Bojić Elma, Marjanović Damir, Božina Nada, Ziegler Christiane, Wolf Christiane, Warrings Bodo, Domschke Katharina, Deckert Jürgen, Babić Dragan

机构信息

Department of Clinical Biochemistry, University Clinical Centre of Kosovo, Prishtina, Kosovo.

出版信息

Psychiatr Danub. 2019 Jun;31(2):241-248. doi: 10.24869/psyd.2019.241.

DOI:10.24869/psyd.2019.241

PMID:31291232

Abstract

BACKGROUND

Posttraumatic stress disorder (PTSD) is a disorder that occurs in some people who have experienced a severe traumatic event. Several genetic studies suggest that gene encoding proteins of catechol-O-methyl-transferase (COMT) may be relevant for the pathogenesis of PTSD. Some researchers suggested that the elevation of interleukin-6 (IL6) correlates with major depression and PTSD. The aim of this study was to investigate whether the single nucleotide polymorphisms COMT rs4680 (Val158Met) and IL6 rs1800795 are associated with PTSD and contribute to the severity of PTSD symptoms.

SUBJECTS AND METHODS

This study comprised 747 participants that experienced war between 1991 and 1999 in the South Eastern Europe conflicts. COMT rs4680 (Val158Met) and IL6 rs1800795 genotypes were determined in 719 participants (369 with and 350 without PTSD). The Mini International Neuropsychiatric Interview (M.I.N.I.), the Clinician Administrated PTSD Scale (CAPS) questionnaire and the Brief Symptom Inventory (BSI) were used for data collection.

RESULTS

Regarding the COMT gene polymorphism, the results of the regression analyses for BSI total score were significant in the lifetime PTSD group in the dominant (P=0.031) and the additive allelic model (P=0.047). Regarding the IL6 gene, a significant difference was found for the recessive model predicting CAPS total score in the lifetime PTSD group (P=0.048), and indicated an association between the C allele and higher CAPS scores. n the allelic, genotypic and rezessive model, the results for BSI total score were significant in the lifetime PTSD group (P=0.033, P=0.028 and P=0.009), suggesting a correlation of the C allele with higher BSI scores.

CONCLUSION

Although our nominally significant results did not withstand correction for multiple tests they may support a relevance of the COMT (Val158Met) and IL6 rs1800795 polymorphism for aspects of PTSD in war traumatized individuals.

摘要

背景

创伤后应激障碍（PTSD）是一种发生在一些经历过严重创伤事件的人身上的疾病。多项基因研究表明，编码儿茶酚-O-甲基转移酶（COMT）蛋白的基因可能与PTSD的发病机制有关。一些研究人员认为，白细胞介素-6（IL6）水平升高与重度抑郁症和PTSD相关。本研究的目的是调查单核苷酸多态性COMT rs4680（Val158Met）和IL6 rs1800795是否与PTSD相关，并对PTSD症状的严重程度有影响。

对象与方法

本研究纳入了747名在1991年至1999年东南欧冲突中经历过战争的参与者。在719名参与者（369名患有PTSD和350名未患PTSD）中确定了COMT rs4680（Val158Met）和IL6 rs1800795基因型。使用迷你国际神经精神访谈（M.I.N.I.）、临床医生管理的PTSD量表（CAPS）问卷和简明症状量表（BSI）进行数据收集。

结果

关于COMT基因多态性，在终身PTSD组中，BSI总分的回归分析结果在显性（P=0.031）和加性等位基因模型（P=0.047）中具有统计学意义。关于IL6基因，在终身PTSD组中，预测CAPS总分的隐性模型存在显著差异（P=0.048），表明C等位基因与较高的CAPS评分之间存在关联。在等位基因、基因型和隐性模型中，终身PTSD组中BSI总分的结果具有统计学意义（P=0.033、P=0.028和P=0.009），表明C等位基因与较高的BSI评分相关。