Departamento de Psiquiatria, Universidade Federal de São Paulo, Rua Botucatu 431 - Villa Clementino, CEP 04023-061, São Paulo, SP, Brazil.
J Mol Neurosci. 2011 Mar;43(3):516-23. doi: 10.1007/s12031-010-9474-2. Epub 2010 Nov 17.
PTSD is a psychiatric disorder that requires a traumatic event as diagnostic criteria. Brazil has high rates of violence, and it is expected that urban victims of violence would be at risk to the development of PTSD. Studies have associated the COMT val158met polymorphism with diminished stress resilience, reduced ability to extinguish conditioned fear, and the development of PTSD after multiple traumatic experiences. The aim of this study was to identify, in a case-control study, whether the val158met polymorphism (rs4860) is associated with the development of PTSD in a group of victims of urban violence. To our knowledge, this is the first study that examines the association between PTSD and urban violence. The polymorphism of COMT in PTSD patients (n=65) as well as in victims of violence without PTSD (n=34) and in a community control group (n=335) were genotyped. We found a significant relationship between the met allele (p<0.02) and PTSD among cases (PTSD+)and victims of violence without PTSD (PTSD-; OR 2.57) and between cases and community control group (p<0.003) Further analysis with larger samples and another ethnic group should be necessary to confirm our findings.
创伤后应激障碍（PTSD）是一种需要创伤事件作为诊断标准的精神障碍。巴西的暴力发生率很高，预计城市暴力受害者将面临患上 PTSD 的风险。研究表明，COMT val158met 多态性与应激耐受力降低、条件性恐惧消除能力降低以及多次创伤经历后 PTSD 的发展有关。本研究旨在通过病例对照研究，确定 COMT val158met 多态性（rs4860）是否与城市暴力受害者中 PTSD 的发生有关。据我们所知，这是第一项研究 PTSD 与城市暴力之间关联的研究。对 PTSD 患者（n=65）、无 PTSD 的暴力受害者（n=34）和社区对照组（n=335）中的 COMT 多态性进行了基因分型。我们发现，在病例（PTSD+）和无 PTSD 的暴力受害者（PTSD-；OR 2.57）中，met 等位基因（p<0.02）与 PTSD 之间存在显著关系，在病例和社区对照组（p<0.003）之间也存在显著关系。需要进一步分析更大的样本和另一个种族群体，以确认我们的发现。
