Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
J Anxiety Disord. 2013 Oct;27(7):678-83. doi: 10.1016/j.janxdis.2013.08.003. Epub 2013 Aug 27.
Posttraumatic stress disorder (PTSD) is a moderately heritable anxiety disorder that may develop after exposure to trauma. However, only few genetic variants that relate to PTSD have been studied. This study examined the relationship between 12 single nucleotide polymorphisms (SNPs) in the corticotropin-releasing hormone receptor 1 gene (CRHR1) and post-disaster PTSD symptoms and diagnosis in adults exposed to 2004 Florida hurricanes. CRHR1 regulates the hypothalamic-pituitary-adrenal (HPA) axis; dysregulation of the HPA axis is characteristic of stress phenotypes. Final analyses were conducted in the European-American (EA) subsample (n=564) due to population stratification. After correction for multiple testing, rs12938031 and rs4792887 remained associated with post-hurricane PTSD symptoms. Additionally, rs12938031 was associated with post-hurricane diagnosis of PTSD. This study is the first to examine CRHR1 in relation to PTSD in adults, and provides evidence for the importance of CRHR1 variation in the etiology of PTSD. Although results are preliminary and require replication, they justify follow-up efforts to characterize how this gene relates to PTSD.
创伤后应激障碍（PTSD）是一种中度遗传性焦虑障碍，可能在创伤后发生。然而，仅有少数与 PTSD 相关的遗传变异得到了研究。本研究调查了 12 个皮质醇释放激素受体 1 基因（CRHR1）单核苷酸多态性（SNP）与经历 2004 年佛罗里达飓风的成年人灾后 PTSD 症状和诊断之间的关系。CRHR1 调节下丘脑-垂体-肾上腺（HPA）轴；HPA 轴的失调是应激表型的特征。由于人群分层，最终分析仅在欧洲裔美国人（EA）亚组（n=564）中进行。在进行多次检验校正后，rs12938031 和 rs4792887 仍与飓风后 PTSD 症状相关。此外，rs12938031 与飓风后 PTSD 的诊断相关。本研究首次在成人 PTSD 中检验了 CRHR1，并为 CRHR1 变异在 PTSD 发病机制中的重要性提供了证据。尽管结果初步且需要复制，但它们证明了后续努力的合理性，以描述该基因与 PTSD 的关系。
