Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan.
Hepatol Res. 2010 Apr;40(4):311-7. doi: 10.1111/j.1872-034X.2009.00599.x. Epub 2010 Jan 4.
The changes in the serum hepatocyte growth factor (HGF) and transforming growth factor (TGF)-beta1 levels after portal vein embolization (PVE), and their clinical significance, remain unclear and we aimed to assess their relationship.
The serum HGF and TGF-beta1 levels were prospectively measured in 22 patients before and 1, 3, 5, 7, and 14 day after right PVE. Computed tomographic volumetry was performed before and at a mean of 26 +/- 4 days after right PVE.
Three to four weeks after right PVE, the volume of embolized lobe significantly decreased from 704 +/- 157 cm(3) before PVE to 539 +/- 168 cm(3) after PVE (P < 0.001). In contrast, the volume of nonembolized lobe significantly increased from 426 +/- 142 cm(3) to 560 +/- 165 cm(3) (P < 0.001). The serum HGF level significantly increased on day 3 after PVE compared with the pretreatment level (P = 0.005), while the serum TGF-beta1 level significantly decreased and reached its lowest value on day 3 (P = 0.002). Using Pearson's correlation analysis, we found that the serum HGF and TGF-beta1 levels on day 14 negatively associated with the large hypertrophic response in the nonembolized lobe (HGF: r = -0.490, P = 0.021; TGF-beta1: r = -0.473, P = 0.026).
PVE induced an increase in the serum HGF level and reduced the serum TGF-beta1 level. Measurement of serum HGF and TGF-beta1 levels on day 14 after right PVE may be useful for assessment of the future liver hypertrophy in nonembolized lobe after right PVE.
门静脉栓塞（PVE）后血清肝细胞生长因子（HGF）和转化生长因子-β1（TGF-β1）水平的变化及其临床意义尚不清楚，本研究旨在评估它们之间的关系。
前瞻性检测 22 例患者 PVE 前及 PVE 后 1、3、5、7、14 天血清 HGF 和 TGF-β1 水平，采用 CT 容积测量法在 PVE 后 26±4 天测量右叶栓塞前和栓塞后的体积。
PVE 后 3~4 周，右叶栓塞体积从 PVE 前的 704±157cm3显著减少至 PVE 后的 539±168cm3（P<0.001），而未栓塞叶的体积从 426±142cm3显著增加至 560±165cm3（P<0.001）。与治疗前相比，PVE 后第 3 天血清 HGF 水平显著升高（P=0.005），而血清 TGF-β1 水平显著降低，于第 3 天达最低值（P=0.002）。Pearson 相关分析显示，第 14 天血清 HGF 和 TGF-β1 水平与未栓塞叶的大体积增生反应呈负相关（HGF：r=-0.490，P=0.021；TGF-β1：r=-0.473，P=0.026）。
PVE 可引起血清 HGF 水平升高，TGF-β1 水平降低。PVE 后第 14 天测量血清 HGF 和 TGF-β1 水平可能有助于评估 PVE 后右叶非栓塞侧未来肝脏的增生反应。
