Behling-Kelly Erica, Petersen Sophie, Muthuswamy Anantharaman, Webb Julie L, Young Karen M
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
Vet Clin Pathol. 2010 Jun;39(2):247-52. doi: 10.1111/j.1939-165X.2009.00211.x. Epub 2010 Jan 7.
A 12-year-old female spayed Labrador Retriever was presented with a history of seizures and abnormal vocalization. Approximately 1 year before presentation, multiple mammary cysts had been surgically excised. A mammary mass was noted on physical examination, and 2 separate parenchymal brain lesions were found on imaging studies. Cerebrospinal fluid (CSF) collected from the cisterna magna was analyzed, and abnormalities included moderate pleocytosis with atypical discrete round cells that occasionally formed loose clusters. The dog was euthanized, and on necropsy a primary solid mammary carcinoma was identified as well as multiple metastatic foci in the brain with diffuse meningeal involvement. The cells in the CSF had a morphologic appearance similar to the cells in the primary mammary tumor and in the metastatic tumors in the brain. On immunostaining, cells from the primary mammary tumor, the brain tumors, and the CSF expressed cytokeratin. The CSF cells did not express CD18, CD3, or CD79a. A final diagnosis of mammary carcinoma with brain metastasis and meningeal carcinomatosis was made.
一只12岁已绝育的雌性拉布拉多寻回犬因癫痫发作和发声异常前来就诊。在就诊前约1年，多个乳腺囊肿已通过手术切除。体格检查发现一个乳腺肿块，影像学检查发现2个独立的脑实质病变。对从枕大池采集的脑脊液（CSF）进行分析，异常包括中度细胞增多，伴有非典型离散圆形细胞，这些细胞偶尔形成松散的细胞团。该犬实施安乐死，尸检时发现原发性实体乳腺腺癌以及脑内多个转移灶，伴有弥漫性脑膜受累。脑脊液中的细胞形态与原发性乳腺肿瘤和脑内转移瘤中的细胞相似。免疫染色显示，原发性乳腺肿瘤、脑肿瘤和脑脊液中的细胞均表达细胞角蛋白。脑脊液细胞不表达CD18、CD3或CD79a。最终诊断为乳腺腺癌伴脑转移和脑膜癌病。
