Singapore National Eye Center, Singapore.
Invest Ophthalmol Vis Sci. 2010 Jun;51(6):2993-7. doi: 10.1167/iovs.09-4418. Epub 2010 Jan 13.
To compare EyeCam (Clarity Medical Systems, Pleasanton, CA) imaging with gonioscopy for detecting angle closure.
In this prospective, hospital-based study, subjects underwent gonioscopy by a single observer and EyeCam imaging by a different operator. EyeCam images were graded by two masked observers. The anterior chamber angle in a quadrant was classified as closed if the trabecular meshwork could not be seen. The eye was classified as having angle closure if two or more quadrants were closed.
One hundred fifty-two subjects were studied. The mean age was 57.4 years (SD 12.9) and there were 82 (54%) men. Of the 152 eyes, 21 (13.8%) had angle closure. The EyeCam provided clear images of the angles in 98.8% of subjects. The agreement between the EyeCam and gonioscopy for detecting angle closure in the superior, inferior, nasal, and temporal quadrants based on agreement coefficient (AC1) statistics was 0.73, 0.75, 0.76, and 0.72, respectively. EyeCam detected more closed angles than did gonioscopy in all quadrants (P < 0.05). With gonioscopy, 21/152 (13.8%) eyes were diagnosed as angle closure compared to 41 (27.0%) of 152 with EyeCam (P < 0.001, McNemar Test), giving an overall sensitivity of 76.2% (95% confidence interval [CI], 54.9%-90.7%), specificity of 80.9% (95%CI, 73.5%-87.3%), and an area under the receiver operating characteristic curve (AUC) of 0.79.
The EyeCam showed good agreement with gonioscopy for detecting angle closure. However, it detected more closed angles than did gonioscopy in all quadrants.
比较 EyeCam（加利福尼亚州普莱森顿的 Clarity Medical Systems）成像与房角镜检查用于检测房角关闭。
在这项前瞻性、基于医院的研究中，受试者接受了一位观察者的房角镜检查和另一位操作者的 EyeCam 成像。两位盲法观察者对 EyeCam 图像进行分级。如果小梁网无法看到，则将象限中的前房角分类为关闭。如果两个或更多象限关闭，则将眼睛分类为具有房角关闭。
共研究了 152 名受试者。平均年龄为 57.4 岁（标准差 12.9），其中 82 名（54%）为男性。在 152 只眼中，有 21 只（13.8%）存在房角关闭。EyeCam 能够清晰显示 98.8%的受试者的角度图像。EyeCam 与房角镜检查在检测上、下、鼻和颞象限的房角关闭的一致性，基于一致性系数（AC1）统计，分别为 0.73、0.75、0.76 和 0.72。EyeCam 在所有象限中检测到的关闭角度均多于房角镜检查（P < 0.05）。在房角镜检查中，21/152（13.8%）只眼被诊断为房角关闭，而 EyeCam 检查中为 41/152（27.0%）（P < 0.001，McNemar 检验），总体敏感性为 76.2%（95%置信区间 [CI]，54.9%-90.7%），特异性为 80.9%（95%CI，73.5%-87.3%），接受者操作特征曲线下面积（AUC）为 0.79。
EyeCam 与房角镜检查在检测房角关闭方面具有良好的一致性。然而，它在所有象限中检测到的关闭角度均多于房角镜检查。
