Akarcay Mustafa, Ekici Nur, Miman Murat C, Firat Yezdan, Bayindir Tuba, Selimoglu Erol
Otorhinolaryngology Department, Medical Faculty, Inonu University, Malatya, Turkey.
J Craniofac Surg. 2010 Jan;21(1):71-4. doi: 10.1097/SCS.0b013e3181c3b785.
To investigate the clinical and laboratory outcomes both objectively and subjectively in nasal polyposis patients with or without comorbidity (CoM; asthma and allergy).
Thirty-three nasal polyposis patients (13 women and 20 men) were included into the study. Their mean age was 39.23 +/- 9.13 years. CoM(+) and CoM(-) nasal polyposis patients were compared with each other. Evaluations contained endoscopic nasal examination, acoustic rhinometry, rhinomanometry, visual analog scale score of nasal blockage, olfactory function score, respiratory function test, skin prick tests, and paranasal sinus computed tomography.
Recovery was statistically significant in all observed evaluations for endoscopic and radiologic staging, nasal obstruction, and sense of smell compared with the first evaluation in all patients regardless of the subgroups. Although objective measurements of respiratory functions did not show any change, clinical improvement was detected in CoM(+) patients with a decrease of need to their antiasthmatic medical treatment.
Results of CoM(+) patients led to no statistical difference when compared with CoM(-) subgroup. When applying predefined nasal polyposis treatment protocol, the polyp patients with CoMs do not need close follow-up compared to the patients without CoMs.
客观和主观地研究合并或未合并其他疾病（合并症；哮喘和过敏）的鼻息肉患者的临床和实验室检查结果。
33例鼻息肉患者（13名女性和20名男性）纳入研究。他们的平均年龄为39.23±9.13岁。对合并症阳性（CoM(+)）和合并症阴性（CoM(-)）的鼻息肉患者进行相互比较。评估内容包括鼻内镜检查、鼻声反射、鼻阻力测量、鼻阻塞视觉模拟量表评分、嗅觉功能评分、呼吸功能测试、皮肤点刺试验和鼻窦计算机断层扫描。
与所有患者的首次评估相比，无论亚组如何，在所有观察到的内镜和放射学分期、鼻阻塞和嗅觉评估中恢复均具有统计学意义。尽管呼吸功能的客观测量未显示任何变化，但CoM(+)患者的临床症状有所改善，哮喘药物治疗需求减少。
与CoM(-)亚组相比，CoM(+)患者的结果无统计学差异。应用预定义的鼻息肉治疗方案时，与无合并症的患者相比，合并症的息肉患者不需要密切随访。
