Hori Junko
Department of Ophthalmology, Nippon Medical School, Sendagi 1-1-5, Bunkyo-ku, Tokyo, 113-8603 Japan.
J Ocul Biol Dis Infor. 2008 Dec;1(2-4):94-100. doi: 10.1007/s12177-008-9010-6. Epub 2008 Aug 8.
The eye, like the brain and reproductive organs, possesses inherent immune privilege, and inflammation is self-regulated so as to preserve the organ functions. Studies over the past 30 years have provided insights of the multiple mechanisms of immune privilege. At present, three major lines of thought prevail regarding the molecular mechanisms of immune privilege in the eye: there are (1) anatomical, cellular, and molecular barriers in the eye; (2) eye-derived immunological tolerance, the so-called anterior chamber-associated immune deviation; and (3) immune suppressive intraocular microenvironment. In this review, the mechanisms of immune privilege that have been learned from ocular inflammation animal models, especially corneal transplantation, are described. Roles of new B7 family molecules on local immune regulation within the cornea are also introduced.
眼睛与大脑和生殖器官一样，具有内在的免疫赦免特性，炎症会自我调节以维持器官功能。过去30年的研究揭示了免疫赦免的多种机制。目前，关于眼睛免疫赦免的分子机制主要有三种观点：（1）眼睛中的解剖学、细胞和分子屏障；（2）眼睛产生的免疫耐受，即所谓的前房相关免疫偏离；（3）免疫抑制性眼内微环境。在这篇综述中，将描述从眼部炎症动物模型，特别是角膜移植模型中学到的免疫赦免机制。还将介绍新的B7家族分子在角膜局部免疫调节中的作用。
