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基于肠促胰岛素的疗法在2型糖尿病管理中的作用。

The role of incretin-based therapies in the management of type 2 diabetes.

作者信息

Bandyopadhyay Prabirkumar

机构信息

Sandwell Medical Research Unit, Sandwell and West Birmingham Hospitals NHS Trust, Lyndon, West Bromwich, West Midlands, B71 4HJ, UK.

出版信息

Drug News Perspect. 2009 Nov;22(9):559-67. doi: 10.1358/dnp.2009.22.9.1434633.

DOI:10.1358/dnp.2009.22.9.1434633
PMID:20072733
Abstract

Type 2 diabetes (T2D) is associated with a greatly increased risk of cardiovascular disease. An increasing need for glucose-lowering treatments is emphasized by the almost inevitable failure of monotherapy and occurrence of weight gain. Recently, novel classes of drugs derived from the incretin system have been introduced into the management of T2D. Recent advances in the field of incretin-based therapies in the management of T2D were discussed at the 45th Annual Meeting of the European Association for the Study of Diabetes, held from September 29 until October 2, 2009, in Vienna, Austria.

摘要

2型糖尿病(T2D)与心血管疾病风险大幅增加相关。单药治疗几乎不可避免的失败以及体重增加的发生凸显了对降糖治疗的需求日益增加。最近,源自肠促胰岛素系统的新型药物已被引入到2型糖尿病的管理中。2009年9月29日至10月2日在奥地利维也纳举行的第45届欧洲糖尿病研究协会年会上讨论了基于肠促胰岛素疗法在2型糖尿病管理领域的最新进展。

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The role of incretin-based therapies in the management of type 2 diabetes.基于肠促胰岛素的疗法在2型糖尿病管理中的作用。
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[Innovations in the treatment of type 2 diabetes mellitus: use of incretins].[2型糖尿病治疗的创新:肠促胰岛素的应用]
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Incretin therapy and its effect on body weight in patients with diabetes.肠促胰岛素治疗及其对糖尿病患者体重的影响。
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The cardiovascular safety trials of DPP-4 inhibitors, GLP-1 agonists, and SGLT2 inhibitors.二肽基肽酶-4 抑制剂、胰高血糖素样肽-1 激动剂和钠-葡萄糖共转运蛋白 2 抑制剂的心血管安全性试验。
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Differentiating among incretin therapies: a multiple-target approach to type 2 diabetes.区分肠促胰岛素治疗:2 型糖尿病的多靶点方法。
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Q: Do incretin drugs for type 2 diabetes increase the risk of acute pancreatitis?问:用于2型糖尿病的肠促胰岛素药物会增加急性胰腺炎的风险吗?
Cleve Clin J Med. 2010 Aug;77(8):503-5. doi: 10.3949/ccjm.77a.09167.
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Incretin-based therapies: facing the realities of benefits versus side effects.基于肠促胰岛素的疗法:面对益处与副作用的现实情况。
Diabetes Technol Ther. 2013 Nov;15(11):909-13. doi: 10.1089/dia.2013.0274. Epub 2013 Oct 10.
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Incretin-based agents in type 2 diabetic patients at cardiovascular risk: compare the effect of GLP-1 agonists and DPP-4 inhibitors on cardiovascular and pancreatic outcomes.存在心血管风险的2型糖尿病患者使用基于肠促胰岛素的药物:比较胰高血糖素样肽-1激动剂和二肽基肽酶-4抑制剂对心血管和胰腺结局的影响。
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