Pradhan Pallab, Banerjee Rinti, Bahadur Dhirendra, Koch Christian, Mykhaylyk Olga, Plank Christian
School of Biosciences and Bioengineering, IIT Bombay, Mumbai, India.
Methods Mol Biol. 2010;605:279-93. doi: 10.1007/978-1-60327-360-2_19.
Targeted delivery systems for anticancer drugs are urgently needed to achieve maximum therapeutic efficacy by site-specific accumulation and thereby minimizing adverse effects resulting from systemic distribution of many potent anticancer drugs. We have prepared folate receptor targeted magnetic liposomes loaded with doxorubicin, which are designed for tumor targeting through a combination of magnetic and biological targeting. Furthermore, these liposomes are designed for hyperthermia-induced drug release to be mediated by an alternating magnetic field and to be traceable by magnetic resonance imaging (MRI). Here, detailed preparation and relevant characterization techniques of targeted magnetic liposomes encapsulating doxorubicin are described.
迫切需要抗癌药物的靶向递送系统，以通过位点特异性积累实现最大治疗效果，从而将许多强效抗癌药物全身分布所产生的副作用降至最低。我们制备了负载阿霉素的叶酸受体靶向磁性脂质体，其通过磁性和生物靶向相结合的方式设计用于肿瘤靶向。此外，这些脂质体设计为由交变磁场介导热诱导药物释放，并可通过磁共振成像（MRI）进行追踪。在此，描述了包裹阿霉素的靶向磁性脂质体的详细制备方法和相关表征技术。
