Small Animal Clinic, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, Hannover 30173, Germany.
J Biomed Mater Res A. 2010 Jun 15;93(4):1609-19. doi: 10.1002/jbm.a.32639.
MgCa0.8 cylinders (2.5 x 25 mm(2)) were coated with a magnesium-fluoride layer and implanted in the marrow cavities of both tibiae of 10 New Zealand White rabbits. The implantation duration was 3 and 6 months. The implants were clinically well tolerated. Micro-computed tomography revealed a new bone formation at the edges of the implants as well as an endosteal and periosteal remodeling. Using EDX-analysis, a calcium and phosphorus rich degradation layer could be found on the implant surface. It was covered by an incomplete layer containing fluoride. The analysis by weight before implantation and after 3 and 6 months, respectively, showed a slight decrease in volume in comparison to uncoated implants. When compared with uncoated implants, the mechanical properties of the coated implants exhibited a reduction in strength after 3 months. After 6 months, the strength of the coated implants was higher than that of uncoated cylinders.
MgCa0.8 圆柱（2.5 x 25 毫米（2））涂有氟化镁层，并植入 10 只新西兰白兔的双侧胫骨骨髓腔中。植入时间为 3 个月和 6 个月。植入物临床耐受性良好。微计算机断层扫描显示在植入物边缘有新骨形成，以及骨内膜和骨膜重塑。通过 EDX 分析，在植入物表面可以发现一层富含钙和磷的降解层。它被一层不完全含氟的层覆盖。植入前和植入后 3 个月和 6 个月的重量分析表明，与未涂层植入物相比，体积略有减少。与未涂层植入物相比，涂层植入物的机械性能在 3 个月后强度降低。6 个月后，涂层植入物的强度高于未涂层圆柱。
