Department of Process Research, Merck Sharp and Dohme Research Laboratories, Hertford Road, Hoddesdon, Hertfordshire, EN11 9BU, United Kingdom.
Org Lett. 2010 Feb 19;12(4):668-71. doi: 10.1021/ol902636v.
A novel synthesis of 3-methylindoles from chlorotriflates through a Heck reaction, carbamate/aryl chloride coupling, and isomerization sequence is presented. The three-step sequence is highly efficient and general, enabling the regiocontrolled synthesis of substituted indoles in short order.
本文提出了一种通过 Heck 反应、氨基甲酸酯/芳基氯偶联和异构化序列从三氟氯乙酸酯合成 3-甲基吲哚的新方法。该三步序列具有高效和通用性，能够在短时间内实现取代吲哚的区域控制合成。
